Development and Validation of Comprehensive Inflammatory Lifestyle Score and Association with Colorectal Cancer Risk.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
814 participants.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSIONS] The validated hypothesis-driven and empirically derived CILS was positively associated with colorectal cancer risk in the UK Biobank. [IMPACT] CILS may offer promising applications in cancer prevention.
[BACKGROUND] A comprehensive inflammatory lifestyle score (CILS) incorporating both dietary and non-dietary factors is lacking.
- 표본수 (n) 4,108
APA
Zheng J, Zhao L, et al. (2025). Development and Validation of Comprehensive Inflammatory Lifestyle Score and Association with Colorectal Cancer Risk.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 34(10), 1810-1819. https://doi.org/10.1158/1055-9965.EPI-25-0386
MLA
Zheng J, et al.. "Development and Validation of Comprehensive Inflammatory Lifestyle Score and Association with Colorectal Cancer Risk.." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, vol. 34, no. 10, 2025, pp. 1810-1819.
PMID
40704925 ↗
Abstract 한글 요약
[BACKGROUND] A comprehensive inflammatory lifestyle score (CILS) incorporating both dietary and non-dietary factors is lacking. This study aimed to develop and validate CILS and assess its association with colorectal cancer risk.
[METHODS] Eligible participants in the UK Biobank with data on baseline lifestyle factors and serum biomarkers measured 2 years later were randomly divided into training (N = 4,108) and validation (N = 1,760) datasets based on sex, age, and race. Reduced rank regression followed by stepwise linear regression identified significant lifestyle factors (i.e., components of CILS) correlated with high-sensitivity C-reactive protein and white blood cell count from 24 a priori-selected inflammation-related factors. CILS was validated using multiple linear regression. Cox models were applied to examine the associations of CILS with incidence and mortality risk of colorectal cancer and subtypes in the remaining 182,814 participants.
[RESULTS] CILS comprised three anti-inflammatory factors [low body weight (body mass index <18.5), higher intake of fish, and apples/berries] and five pro-inflammatory factors [obesity/overweight, prolonged sedentary time (the highest tertile in the population), current smoking, whole-fat dairy, and processed meat], with higher CILS indicating a more pro-inflammatory lifestyle. Validation analyses demonstrated a 22.2% and 2.8% increase in high-sensitivity C-reactive protein and white blood cell count for each SD increment in CILS, respectively. Higher CILS was linked to increased colorectal cancer incidence (HRper SD increase = 1.12; 95% confidence interval, 1.08-1.16) and mortality (HRper SD increase = 1.18; 95% confidence interval, 1.08-1.28) and increased risk of all colorectal cancer subtypes except incident rectal cancer.
[CONCLUSIONS] The validated hypothesis-driven and empirically derived CILS was positively associated with colorectal cancer risk in the UK Biobank.
[IMPACT] CILS may offer promising applications in cancer prevention.
[METHODS] Eligible participants in the UK Biobank with data on baseline lifestyle factors and serum biomarkers measured 2 years later were randomly divided into training (N = 4,108) and validation (N = 1,760) datasets based on sex, age, and race. Reduced rank regression followed by stepwise linear regression identified significant lifestyle factors (i.e., components of CILS) correlated with high-sensitivity C-reactive protein and white blood cell count from 24 a priori-selected inflammation-related factors. CILS was validated using multiple linear regression. Cox models were applied to examine the associations of CILS with incidence and mortality risk of colorectal cancer and subtypes in the remaining 182,814 participants.
[RESULTS] CILS comprised three anti-inflammatory factors [low body weight (body mass index <18.5), higher intake of fish, and apples/berries] and five pro-inflammatory factors [obesity/overweight, prolonged sedentary time (the highest tertile in the population), current smoking, whole-fat dairy, and processed meat], with higher CILS indicating a more pro-inflammatory lifestyle. Validation analyses demonstrated a 22.2% and 2.8% increase in high-sensitivity C-reactive protein and white blood cell count for each SD increment in CILS, respectively. Higher CILS was linked to increased colorectal cancer incidence (HRper SD increase = 1.12; 95% confidence interval, 1.08-1.16) and mortality (HRper SD increase = 1.18; 95% confidence interval, 1.08-1.28) and increased risk of all colorectal cancer subtypes except incident rectal cancer.
[CONCLUSIONS] The validated hypothesis-driven and empirically derived CILS was positively associated with colorectal cancer risk in the UK Biobank.
[IMPACT] CILS may offer promising applications in cancer prevention.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
같은 제1저자의 인용 많은 논문 (5)
- A gradient boosting decision tree based estimation method for the mixture cure model.
- The analysis of the leukemia mortality rate and its temporal trends in China from 2004 to 2021.
- Hippocampal-amygdala subregional characteristic changes predict heterogeneous post-chemotherapy neuropsychological outcomes.
- Successful Treatment of Oxaliplatin-Induced Immune Thrombocytopenia in a Schizophrenic Patient With Contraindication to Steroids Using Cyclosporine Plus Eltrombopag: A Case Report.
- Prospective evaluation of radical surgery for adenocarcinoma of oesophagogastric junction: real-world insights from the CLAEG study.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Comprehensive analysis of androgen receptor splice variant target gene expression in prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.