Sex disparity in hepatocellular carcinoma recurrence after curative liver resection: a multicenter comprehensive analysis.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
Hazard curves representing the changes in risk of recurrence over time were evaluated.
I · Intervention 중재 / 시술
curative-intent resection for HCC between July 2015 and June 2020 were identified from a multicenter database and analyzed retrospectively
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
A lower risk of HCC recurrence was also found in females in the sensitive analysis. [CONCLUSION] Male patients had a higher risk of HCC recurrence than females after surgery, and recurrence hazard rates for different sexes varied substantially with respect to both time and peak rates.
[BACKGROUND AND AIMS] The impact of sex disparity on the patterns of recurrence after curative resection of hepatocellular carcinoma (HCC) remains controversial.
- p-value P = 0.008
APA
Dai MG, Liu SY, et al. (2025). Sex disparity in hepatocellular carcinoma recurrence after curative liver resection: a multicenter comprehensive analysis.. European journal of gastroenterology & hepatology, 37(11), 1275-1282. https://doi.org/10.1097/MEG.0000000000003024
MLA
Dai MG, et al.. "Sex disparity in hepatocellular carcinoma recurrence after curative liver resection: a multicenter comprehensive analysis.." European journal of gastroenterology & hepatology, vol. 37, no. 11, 2025, pp. 1275-1282.
PMID
40631508 ↗
Abstract 한글 요약
[BACKGROUND AND AIMS] The impact of sex disparity on the patterns of recurrence after curative resection of hepatocellular carcinoma (HCC) remains controversial. The aim of this study was to comprehensively investigate the influence of sex differences in HCC recurrence following curative hepatectomy.
[METHODS] Patients who underwent curative-intent resection for HCC between July 2015 and June 2020 were identified from a multicenter database and analyzed retrospectively. Tumor recurrence was evaluated using Cox regression and Kaplan-Meier methods. Hazard curves representing the changes in risk of recurrence over time were evaluated. Propensity score matching and a competing risk model were used for sensitivity analysis.
[RESULTS] Of 1570 patients, 1334 (85.0%) were men, and 236 (15.0%) were women. Female patients showed significantly lower risk for HCC recurrence than males in the multivariate Cox regression analysis (hazard rate: 0.75, 95% confidence interval: 0.61-0.93, P = 0.008). Landmark analysis showed that sex was an independent risk factor for late recurrence, but not for early recurrence. The hazard function curve for female patients was relatively flat [peak hazard rates (pHR): 0.0234], while males recurred with a peak at 3.0 months (pHR: 0.0302). A lower risk of HCC recurrence was also found in females in the sensitive analysis.
[CONCLUSION] Male patients had a higher risk of HCC recurrence than females after surgery, and recurrence hazard rates for different sexes varied substantially with respect to both time and peak rates.
[METHODS] Patients who underwent curative-intent resection for HCC between July 2015 and June 2020 were identified from a multicenter database and analyzed retrospectively. Tumor recurrence was evaluated using Cox regression and Kaplan-Meier methods. Hazard curves representing the changes in risk of recurrence over time were evaluated. Propensity score matching and a competing risk model were used for sensitivity analysis.
[RESULTS] Of 1570 patients, 1334 (85.0%) were men, and 236 (15.0%) were women. Female patients showed significantly lower risk for HCC recurrence than males in the multivariate Cox regression analysis (hazard rate: 0.75, 95% confidence interval: 0.61-0.93, P = 0.008). Landmark analysis showed that sex was an independent risk factor for late recurrence, but not for early recurrence. The hazard function curve for female patients was relatively flat [peak hazard rates (pHR): 0.0234], while males recurred with a peak at 3.0 months (pHR: 0.0302). A lower risk of HCC recurrence was also found in females in the sensitive analysis.
[CONCLUSION] Male patients had a higher risk of HCC recurrence than females after surgery, and recurrence hazard rates for different sexes varied substantially with respect to both time and peak rates.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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