Current Focus and Innovation in Liver Transplantation.

Advances in liver transplantation continue to improve survival. For patients with advanced disease, specific selection criteria are implemented to ensure long-term decreases in morbidity and mortality. There has been an increasing role of liver transplantation in several malignancies that include hepatocellular carcinoma, cholangiocarcinoma, colorectal metastatic liver disease, and metastatic neuroendocrine liver disease. Innovative approaches to address the organ shortage include living donor liver transplantation, machine perfusion, and the use of ABO incompatible organs; recent advances in xenotransplantation offer another potential avenue. In this review, we cover some of the more recent focuses, trends, and advances in liver transplantation.