Effect of Fireweed ( L.) Extracts and Oenothein B on Colon Cancer Cells: Impact of Leaf Fermentation on Viability and Mitochondrial Function.
1/5 보강
Fireweed ( L.) possesses antibacterial, antioxidant, anti-inflammatory, and anti-cancer properties.
APA
Uogintaite D, Baniene R, et al. (2025). Effect of Fireweed ( L.) Extracts and Oenothein B on Colon Cancer Cells: Impact of Leaf Fermentation on Viability and Mitochondrial Function.. Medicina (Kaunas, Lithuania), 61(11). https://doi.org/10.3390/medicina61111957
MLA
Uogintaite D, et al.. "Effect of Fireweed ( L.) Extracts and Oenothein B on Colon Cancer Cells: Impact of Leaf Fermentation on Viability and Mitochondrial Function.." Medicina (Kaunas, Lithuania), vol. 61, no. 11, 2025.
PMID
41303794 ↗
Abstract 한글 요약
Fireweed ( L.) possesses antibacterial, antioxidant, anti-inflammatory, and anti-cancer properties. This study evaluated the effects of aqueous fireweed leaf extracts and their major compound, oenothein B, on the viability and mitochondrial function of Caco-2 colon cancer cells, emphasizing the impact of leaf fermentation. : Cells were treated for 48 h with oenothein B and aqueous extracts from unfermented (NF) and fermented leaves (F 24 h, F 48 h). Cell viability and mitochondrial function were assessed by MTT assay and high-resolution respirometry. : IC values were 0.843 mg/mL (NF), 1.548 mg/mL (F 24 h), 1.931 mg/mL (F 48 h), and 0.09 mg/mL (57 µM) (oenothein B). Mitochondrial respiration decreased in up to 67% (glutamate/malate) and 61% (succinate) in both fermented and unfermented groups, while oenothein B increased in leak respiration by 34-73% but reduced oxidative respiration by 24%. Aqueous extracts of fireweed from both unfermented and fermented leaves significantly reduced Caco-2 cell viability and mitochondrial function. Oenothein B on its own had a stronger effect on cell viability, but a weaker effect on mitochondrial function, compared to fireweed extracts.
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