Dietary Diabetes Risk Reduction Score (DDRRS) and the Risk of Colorectal Cancer and Adenoma: A Case-Control Study.

[BACKGROUND] Given the role of insulin resistance in several cancers, we hypothesized that the risk of colorectal cancer and colorectal adenoma may be lessened by following a diet that improves insulin resistance. Therefore, we conducted the current study to examine the association between dietary diabetes risk reduction and the odds of colorectal cancer and colorectal adenoma.

[METHOD] This hospital-based case-control study was conducted on 129 newly diagnosed colorectal cancer patients, 130 newly diagnosed colorectal adenoma cases, and 240 healthy age- and sex-matched hospitalized controls. We used a valid and reliable 148-item food frequency questionnaire (FFQ) to collect the dietary intake of subjects. Multivariate logistic regression was used to estimate the association between DDRRS and the odds of colorectal cancer and adenoma.

[RESULTS] After adjusting for confounding variables, individuals in the highest tertile of the DDRRS were 0.13 and 0.22 times less likely to have colorectal cancer (OR = 0.13, 95% CI: 0.06-0.25) and adenoma (OR = 0.22, 95% CI: 0.12-0.41) respectively.

[CONCLUSION] Current results demonstrated that a high DDRRS was associated with a lower risk of colorectal cancer and adenoma.