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Extracellular Vesicle-Packaged circTAX1BP1 from Cancer-Associated Fibroblasts Regulates RNA m6A Modification through Lactylation of VIRMA in Colorectal Cancer Cells.

1/5 보강

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 📖 저널 OA 92.2% 2023~2026 2025 Vol.12(47) p. e14008

PICO 자동 추출 (휴리스틱, conf 2/4)

유사 논문

P · Population 대상 환자/모집단

환자: colorectal liver metastasis (CRLM) remains unclear

I · Intervention 중재 / 시술

추출되지 않음

C · Comparison 대조 / 비교

추출되지 않음

O · Outcome 결과 / 결론

Finally, the combined blockade of EV-packaged circTAX1BP1 and TGF-β can effectively disrupt this feedback loop and significantly inhibit tumor progression in a PDX model. Overall, this study provides an in-depth understanding of tumor cell-CAFs crosstalk and new insights into therapeutic targets for CRLM.

Tan JN, Yu JH, Hou D, Xie YQ, Lai DM, Zheng F

📖 무료 전문 🟢 PMC 전문 PMC12713077

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

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