← 뒤로

Hyperuricemia exacerbates acetaminophen hepatotoxicity via JNK activation and mitophagy reduction.

1/5 보강
Biochemical pharmacology 📖 저널 OA 10.1% 2022: 0/1 OA 2024: 2/6 OA 2025: 0/49 OA 2026: 15/122 OA 2022~2026 2026 Vol.243(Pt 1) p. 117487
Retraction 확인
출처
PubMed DOI

PICO 자동 추출 (휴리스틱, conf 2/4)

유사 논문
P · Population 대상 환자/모집단
환자: HUA and the role of HUA in APAP-induced hepatotoxicity remain unclear
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Taken together, this study indicates that HUA is a potential risk factor for APAP-induced hepatic injury, exacerbating hepatic cell death through JNK pathway activation and the suppression of mitophagy. These findings offer important insights for guiding APAP administration in patients with HUA.

Liu Y, Peng B, Li D, Chen J, Lai Y, You Y

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

Fatal error: Uncaught PDOException: SQLSTATE[42000]: Syntax error or access violation: 1064 You have an error in your SQL syntax; check the manual that corresponds to your MariaDB server version for the right syntax to use near 'JSON)) ORDER BY n_sources DESC LIMIT 6' at line 3 in /home/prsinsight/public_html/app/core/Database.php:33 Stack trace: #0 /home/prsinsight/public_html/app/core/Database.php(33): PDOStatement->execute() #1 /home/prsinsight/public_html/app/models/WikiPage.php(190): App\Core\Database::fetchAll() #2 /home/prsinsight/public_html/app/views/paper/show.php(671): App\Models\WikiPage::backlinksForPaper() #3 /home/prsinsight/public_html/app/core/View.php(32): include('...') #4 /home/prsinsight/public_html/app/core/View.php(15): App\Core\View->capture() #5 /home/prsinsight/public_html/app/core/Controller.php(21): App\Core\View->render() #6 /home/prsinsight/public_html/app/controllers/PaperController.php(372): App\Core\Controller->render() #7 [internal function]: App\Controllers\PaperController->show() #8 /home/prsinsight/public_html/app/core/Router.php(48): call_user_func_array() #9 /home/prsinsight/public_html/app/core/Router.php(34): App\Core\Router->call() #10 /home/prsinsight/public_html/index.php(286): App\Core\Router->dispatch() #11 {main} thrown in /home/prsinsight/public_html/app/core/Database.php on line 33