Autophagy-mediated quality control of MHC class I molecules regulates tumor evasion.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: hepatocellular carcinoma (HCC) and in a mouse model of HCC
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
The results describe a novel example of autophagy promoting tumor evasion through immunomodulation. Indeed, the study found that lower levels of IRGQ are associated with higher survival rates in patients with hepatocellular carcinoma (HCC) and in a mouse model of HCC.
Antigen presentation by major histocompatibility complex class I (MHC class I) molecules is crucial for activating the T-cell-mediated immune response.
APA
Bhattacharyya D, Klionsky DJ (2026). Autophagy-mediated quality control of MHC class I molecules regulates tumor evasion.. Autophagy, 22(1), 1-2. https://doi.org/10.1080/15548627.2025.2580026
MLA
Bhattacharyya D, et al.. "Autophagy-mediated quality control of MHC class I molecules regulates tumor evasion.." Autophagy, vol. 22, no. 1, 2026, pp. 1-2.
PMID
41449973 ↗
Abstract 한글 요약
Antigen presentation by major histocompatibility complex class I (MHC class I) molecules is crucial for activating the T-cell-mediated immune response. A recent paper by Herhaus and colleagues revealed that IRGQ (immunity related GTPase Q) functions as an autophagy receptor for MHC class I molecules. IRGQ, being an oncogenic macroautophagy/autophagy receptor, also functions as an immune modulator, thus presenting a novel functional example. IRGQ regulates the quality control of MHC class I molecules, thereby influencing the T-cell-mediated immune response; IRGQ directs misfolded MHC class I molecules to autophagic degradation, thereby suppressing the immune response and mediating tumor evasion. Conversely, in the absence of IRGQ, free MHC class I heavy chains can reach the cell surface, potentially enhancing the immune response and suppressing tumor evasion. The results describe a novel example of autophagy promoting tumor evasion through immunomodulation. Indeed, the study found that lower levels of IRGQ are associated with higher survival rates in patients with hepatocellular carcinoma (HCC) and in a mouse model of HCC.
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