Investigating the hepatoprotective effects of : phytochemical, biological, and computational approaches to combat liver damage.
1/5 보강
This study investigates the phytochemical constituents and hepatoprotective properties of Maire & Weiller, a traditional medicinal herb.
APA
Elshibani FA, Farouk A, et al. (2026). Investigating the hepatoprotective effects of : phytochemical, biological, and computational approaches to combat liver damage.. Natural product research, 1-8. https://doi.org/10.1080/14786419.2025.2609189
MLA
Elshibani FA, et al.. "Investigating the hepatoprotective effects of : phytochemical, biological, and computational approaches to combat liver damage.." Natural product research, 2026, pp. 1-8.
PMID
41481366 ↗
Abstract 한글 요약
This study investigates the phytochemical constituents and hepatoprotective properties of Maire & Weiller, a traditional medicinal herb. Phytochemical analysis revealed phenolic acids and flavonoids at concentrations of 3.06 GAE/g and 1.02 CE/g, respectively. LC-ESI-MS/MS identified 35 compounds known for their antioxidant and anti-inflammatory properties. antioxidant assays showed scavenging abilities against DPPH and ABTS free radicals with IC50 values of 198.68 and 151.19 µg/mL. Rats treated with diethylnitrosamine (DEN) exhibited liver injury. Still, those treated with showed nearly normal liver anatomy and significantly lower levels of pro-inflammatory markers compared to the HCC group. Additionally, anti-oxidative stress biomarkers were higher in the treated groups. The higher dose improved DEN-induced liver damage while maintaining healthy hepatocyte structure. Molecular docking indicated potential bioactivity of Onopornoids against specific enzymes, with favourable ADMET characteristics suggesting potential as a natural therapeutic agent for liver protection and cancer treatment.
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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