Preliminary study of Gd-EOB-DTPA contrast-enhanced magnetic resonance imaging for determining gross tumor volume in hepatocellular carcinoma radiotherapy.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
12 patients diagnosed with HCC (18 lesions) who received radiotherapy and underwent magnetic resonance (MR) simulation.
I · Intervention 중재 / 시술
radiotherapy and underwent magnetic resonance (MR) simulation
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSION] CE-TWI MR images acquired more than 20 min post-injection of Gd-EOB-DTPA exhibited significant advantages in determining the GTV boundaries and enhancing the contrast of SI between HCC and liver tissue. The CE-TWI sequence is recommended for determining HCC GTV.
[PURPOSE] The aim of this study was to evaluate the feasibility of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) contrast-enhanced magnetic resonance imaging (CE-MRI) for d
APA
Meng K, Gong G, et al. (2025). Preliminary study of Gd-EOB-DTPA contrast-enhanced magnetic resonance imaging for determining gross tumor volume in hepatocellular carcinoma radiotherapy.. Frontiers in oncology, 15, 1720806. https://doi.org/10.3389/fonc.2025.1720806
MLA
Meng K, et al.. "Preliminary study of Gd-EOB-DTPA contrast-enhanced magnetic resonance imaging for determining gross tumor volume in hepatocellular carcinoma radiotherapy.." Frontiers in oncology, vol. 15, 2025, pp. 1720806.
PMID
41658568 ↗
Abstract 한글 요약
[PURPOSE] The aim of this study was to evaluate the feasibility of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) contrast-enhanced magnetic resonance imaging (CE-MRI) for determining the gross tumor volume (GTV) of hepatocellular carcinoma (HCC).
[METHODS] A retrospective analysis was conducted on 12 patients diagnosed with HCC (18 lesions) who received radiotherapy and underwent magnetic resonance (MR) simulation. Six series images, including MR T-weighted image (TWI) and contrast-enhanced TWI (CE-TWI) at 15 s, 45 s, 75 s, 150 s, and >20 min after Gd-EOB-DTPA injection, were obtained, and the GTV was determined in the different temporal images. The differences in mean signal intensity (SI), SI contrast between the HCC and liver tissue, volume and shape of HCC GTV among different phases were compared.
[RESULTS] (1) The mean SI of liver tissue reached its peak enhancement at >20 min, showing a 140.90 ± 64.69% increase, compared with TWI ( < 0.05). (2) Compared with CE-TWI, the mean SI of the HCC increased by -41.19~18.09% from TWI, CE-TWI to CE-TWI. Conversely, the mean SI of liver tissue decreased by 5.27~55.87% over the same period. Consequently, the SI contrast between HCC and liver tissue decreased by 53.30~89.37%. (3) The maximum GTV volume determined by CE-TWI was (22.80 ± 18.57) cm, coinciding with the highest value of SI contrast (0.29 ± 0.16). (4) Compared with GTV, GTV and GTV~GTV had volume reductions of 6.73~19.35%. (5) Compared with GTV, the Dice similarity coefficients (DSC) of GTV and GTV~GTV ranged from 0.745 to 0.819. Additionally, the shape change trend of GTV in the CE-TWI images was generally consistent with the volume change trend.
[CONCLUSION] CE-TWI MR images acquired more than 20 min post-injection of Gd-EOB-DTPA exhibited significant advantages in determining the GTV boundaries and enhancing the contrast of SI between HCC and liver tissue. The CE-TWI sequence is recommended for determining HCC GTV.
[METHODS] A retrospective analysis was conducted on 12 patients diagnosed with HCC (18 lesions) who received radiotherapy and underwent magnetic resonance (MR) simulation. Six series images, including MR T-weighted image (TWI) and contrast-enhanced TWI (CE-TWI) at 15 s, 45 s, 75 s, 150 s, and >20 min after Gd-EOB-DTPA injection, were obtained, and the GTV was determined in the different temporal images. The differences in mean signal intensity (SI), SI contrast between the HCC and liver tissue, volume and shape of HCC GTV among different phases were compared.
[RESULTS] (1) The mean SI of liver tissue reached its peak enhancement at >20 min, showing a 140.90 ± 64.69% increase, compared with TWI ( < 0.05). (2) Compared with CE-TWI, the mean SI of the HCC increased by -41.19~18.09% from TWI, CE-TWI to CE-TWI. Conversely, the mean SI of liver tissue decreased by 5.27~55.87% over the same period. Consequently, the SI contrast between HCC and liver tissue decreased by 53.30~89.37%. (3) The maximum GTV volume determined by CE-TWI was (22.80 ± 18.57) cm, coinciding with the highest value of SI contrast (0.29 ± 0.16). (4) Compared with GTV, GTV and GTV~GTV had volume reductions of 6.73~19.35%. (5) Compared with GTV, the Dice similarity coefficients (DSC) of GTV and GTV~GTV ranged from 0.745 to 0.819. Additionally, the shape change trend of GTV in the CE-TWI images was generally consistent with the volume change trend.
[CONCLUSION] CE-TWI MR images acquired more than 20 min post-injection of Gd-EOB-DTPA exhibited significant advantages in determining the GTV boundaries and enhancing the contrast of SI between HCC and liver tissue. The CE-TWI sequence is recommended for determining HCC GTV.
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