Effects of a positively charged biomaterial for dermal and subcutaneous augmentation.
Abstract
Based on previous experimental connective tissue work, the use of a positively charged dextran-based biomaterial in subcutaneous tissue sites was evaluated. After hydration with saline, the biomaterial was injected beneath the abdominal skin in rats. A robust macrophage response was initially seen at 30 days without acute inflammation. By one year postoperatively, extensive intermaterial fibroblast and collagen ingrowth had occurred. No evidence of a foreign-body or chronic inflammatory response was seen. These preliminary findings suggest good tissue compatibility of this biomaterial and suggests that when combined with a biocompatible liquid medium, the potential for development of a bioactive dermal and subcutaneous injectable substance exists.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | subcutaneous
|
피하조직 | dict | 3 | |
| 해부 | dermal
|
scispacy | 1 | ||
| 해부 | connective tissue
|
scispacy | 1 | ||
| 해부 | subcutaneous tissue sites
|
scispacy | 1 | ||
| 해부 | skin
|
scispacy | 1 | ||
| 해부 | macrophage
|
scispacy | 1 | ||
| 해부 | fibroblast
|
scispacy | 1 | ||
| 해부 | tissue
|
scispacy | 1 | ||
| 합병증 | subcutaneous injectable
|
scispacy | 1 | ||
| 약물 | saline
|
scispacy | 1 | ||
| 질환 | inflammation
|
C0021368
Inflammation
|
scispacy | 1 | |
| 질환 | foreign-body or chronic inflammatory response
|
scispacy | 1 | ||
| 질환 | foreign-body
|
scispacy | 1 | ||
| 질환 | dermal
|
scispacy | 1 | ||
| 기타 | rats
|
scispacy | 1 | ||
| 기타 | collagen
|
scispacy | 1 |
MeSH Terms
Animals; Cations; Collagen; Connective Tissue; DEAE-Dextran; Dermatologic Surgical Procedures; Female; Fibroblasts; Injections, Subcutaneous; Macrophages; Materials Testing; Rats; Rats, Sprague-Dawley; Skin; Surgery, Plastic; Wound Healing
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