Correlation between liver stiffness measurement and hepatocellular carcinoma risk: A case control study.
Liver stiffness measurement (LSM) using transient elastography (TE) poorly predicts hepatocellular carcinoma risk in cirrhotic patients, despite its established role in fibrosis assessment.
- Sensitivity 80%
- 연구 설계 case-control
APA
Garg A, Gupta YK, et al. (2026). Correlation between liver stiffness measurement and hepatocellular carcinoma risk: A case control study.. Bioinformation, 22(1), 169-174. https://doi.org/10.6026/973206300220169
MLA
Garg A, et al.. "Correlation between liver stiffness measurement and hepatocellular carcinoma risk: A case control study.." Bioinformation, vol. 22, no. 1, 2026, pp. 169-174.
PMID
41960486
Abstract
Liver stiffness measurement (LSM) using transient elastography (TE) poorly predicts hepatocellular carcinoma risk in cirrhotic patients, despite its established role in fibrosis assessment. This case-control study compared 30 hepatocellular carcinoma (HCC) patients with cirrhosis to 30 cirrhosis-only patients using FibroScan® TE for LSM. HCC patients were older, mostly male, with Hepatitis C virus (HCV) as the primary cirrhosis cause, followed by alcohol; median LSM was higher in HCC (58.0 kPa) versus non-HCC (24.5 kPa). Stratum-specific likelihood ratios rose with LSM and multivariate analysis confirmed age, HCV, alcohol and LSM as independent HCC predictors; LSM ≥39.45 kPa showed 83% sensitivity and 80% specificity for HCC detection in cirrhosis. Elevated LSM strongly associates with HCC risk, supporting TE as a non-invasive tool, especially with HCV/alcohol factors.