A multicenter case-controlled study on laparoscopic hepatectomy versus open liver resection as first-line therapy for solitary hepatocellular carcinoma in elderly patients.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
180 patients, 94 and 86 were included in the LLR and OLR groups, respectively.
I · Intervention 중재 / 시술
curative liver resection for single HCC at four tertiary centers between January 2015 and December 2021
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSION] For selected elderly patients with solitary HCC, particularly those with tumors in locations amenable to a minimally invasive approach, LLR was associated with superior perioperative and long-term survival outcomes compared to OLR. [CLINICAL TRIALS REGISTRATION] Not applicable because this is a retrospective observational study.
[PURPOSE] This study aimed to compare perioperative and long-term outcomes between laparoscopic (LLR) and open liver resection (OLR) in elderly patients with solitary hepatocellular carcinoma (HCC).
- p-value p = 0.010
- p-value p = 0.021
APA
Yang S, Zhou S, et al. (2026). A multicenter case-controlled study on laparoscopic hepatectomy versus open liver resection as first-line therapy for solitary hepatocellular carcinoma in elderly patients.. Surgical endoscopy, 40(2), 1089-1105. https://doi.org/10.1007/s00464-025-12364-2
MLA
Yang S, et al.. "A multicenter case-controlled study on laparoscopic hepatectomy versus open liver resection as first-line therapy for solitary hepatocellular carcinoma in elderly patients.." Surgical endoscopy, vol. 40, no. 2, 2026, pp. 1089-1105.
PMID
41196300 ↗
Abstract 한글 요약
[PURPOSE] This study aimed to compare perioperative and long-term outcomes between laparoscopic (LLR) and open liver resection (OLR) in elderly patients with solitary hepatocellular carcinoma (HCC).
[METHODS] The study consecutively included patients aged ≥ 70 years who underwent curative liver resection for single HCC at four tertiary centers between January 2015 and December 2021. Perioperative short-term and long-term survival outcomes were compared between the LLR and OLR groups. Propensity score matching (PSM) was performed in a 1:1 ratio to balance baseline characteristics between the two groups. Univariate and multivariate Cox regression analyses were conducted to identify independent risk factors associated with overall survival (OS) and recurrence-free survival (RFS).
[RESULTS] Of the 180 patients, 94 and 86 were included in the LLR and OLR groups, respectively. After PSM, 65 patients were included in each group. Intraoperative blood loss (p = 0.010), operative time (p = 0.021), length of hospital stay (p = 0.021) and 90-day readmission rate (p = 0.048) were significantly lower in the matched LLR than the matched OLR group. Moreover, postoperative ascites complication was less frequent in the matched LLR group (p = 0.046). Long-term survival outcomes were better in the LLR group compared with the OLR group both before and after PSM (for OS: p = 0.019 and 0.003; for RFS: p = 0.023 and 0.012). Multivariate Cox regression analysis found that open hepatectomy was an independent risk factor of OS and RFS for elderly HCC patients compared to laparoscopic approach.
[CONCLUSION] For selected elderly patients with solitary HCC, particularly those with tumors in locations amenable to a minimally invasive approach, LLR was associated with superior perioperative and long-term survival outcomes compared to OLR.
[CLINICAL TRIALS REGISTRATION] Not applicable because this is a retrospective observational study.
[METHODS] The study consecutively included patients aged ≥ 70 years who underwent curative liver resection for single HCC at four tertiary centers between January 2015 and December 2021. Perioperative short-term and long-term survival outcomes were compared between the LLR and OLR groups. Propensity score matching (PSM) was performed in a 1:1 ratio to balance baseline characteristics between the two groups. Univariate and multivariate Cox regression analyses were conducted to identify independent risk factors associated with overall survival (OS) and recurrence-free survival (RFS).
[RESULTS] Of the 180 patients, 94 and 86 were included in the LLR and OLR groups, respectively. After PSM, 65 patients were included in each group. Intraoperative blood loss (p = 0.010), operative time (p = 0.021), length of hospital stay (p = 0.021) and 90-day readmission rate (p = 0.048) were significantly lower in the matched LLR than the matched OLR group. Moreover, postoperative ascites complication was less frequent in the matched LLR group (p = 0.046). Long-term survival outcomes were better in the LLR group compared with the OLR group both before and after PSM (for OS: p = 0.019 and 0.003; for RFS: p = 0.023 and 0.012). Multivariate Cox regression analysis found that open hepatectomy was an independent risk factor of OS and RFS for elderly HCC patients compared to laparoscopic approach.
[CONCLUSION] For selected elderly patients with solitary HCC, particularly those with tumors in locations amenable to a minimally invasive approach, LLR was associated with superior perioperative and long-term survival outcomes compared to OLR.
[CLINICAL TRIALS REGISTRATION] Not applicable because this is a retrospective observational study.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Carcinoma
- Hepatocellular
- Liver Neoplasms
- Hepatectomy
- Laparoscopy
- Male
- Female
- Aged
- Case-Control Studies
- 80 and over
- Retrospective Studies
- Propensity Score
- Operative Time
- Postoperative Complications
- Treatment Outcome
- Length of Stay
- Elderly patients
- Laparoscopic liver resection
- Long-term survival
- Perioperative outcomes
- Propensity score matching
- Solitary hepatocellular carcinoma
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