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Fibrolamellar carcinoma: The role of imaging in diagnosis and management.

Radiology case reports 2026 Vol.21(2) p. 640-644

Melo-Alvear D, Clarete A, Tascón-Barona AH

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Liver cancer is one of the most prevalent malignancies worldwide, with hepatocellular carcinoma accounting for approximately 80% of primary liver tumors.

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APA Melo-Alvear D, Clarete A, Tascón-Barona AH (2026). Fibrolamellar carcinoma: The role of imaging in diagnosis and management.. Radiology case reports, 21(2), 640-644. https://doi.org/10.1016/j.radcr.2025.10.013
MLA Melo-Alvear D, et al.. "Fibrolamellar carcinoma: The role of imaging in diagnosis and management.." Radiology case reports, vol. 21, no. 2, 2026, pp. 640-644.
PMID 41332959

Abstract

Liver cancer is one of the most prevalent malignancies worldwide, with hepatocellular carcinoma accounting for approximately 80% of primary liver tumors. Fibrolamellar carcinoma is a rare variant that predominantly affects young individuals without underlying liver disease. Due to its nonspecific clinical presentation and the absence of typical risk factors, diagnosis is often delayed until advanced stages. Correlating imaging findings with clinical and histopathological data is essential for accurate diagnosis and effective treatment, highlighting the need for a multidisciplinary approach to managing these rare neoplasms. We present the case of a 15-year-old patient diagnosed with fibrolamellar carcinoma, emphasizing the critical role of imaging in its identification and the importance of an aggressive surgical approach to optimizing long-term outcomes.