Frailty Recovery Following Minimally Invasive Surgery: An Emerging Perspective on Surgical Benefits in Elderly Colorectal Cancer Patients.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
88 patients (37%) were diagnosed as frail on the basis of either of the frailty assessment tools, and MIS was performed in all cases.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSIONS] Curative MIS was safely performed in elderly frail colorectal cancer patients without increasing perioperative complications; however, their long-term outcomes remained poor. Nevertheless, in patients who remained recurrence-free, frailty status significantly improved 1 year after surgery, suggesting an emerging potential benefit of surgical resection in the elderly population.
[BACKGROUND] Frailty is common among elderly colorectal cancer (CRC) patients and affects both perioperative and long-term outcomes.
APA
Ushigome H, Yamakawa Y, et al. (2026). Frailty Recovery Following Minimally Invasive Surgery: An Emerging Perspective on Surgical Benefits in Elderly Colorectal Cancer Patients.. Annals of gastroenterological surgery, 10(1), 137-144. https://doi.org/10.1002/ags3.70070
MLA
Ushigome H, et al.. "Frailty Recovery Following Minimally Invasive Surgery: An Emerging Perspective on Surgical Benefits in Elderly Colorectal Cancer Patients.." Annals of gastroenterological surgery, vol. 10, no. 1, 2026, pp. 137-144.
PMID
41488845
Abstract
[BACKGROUND] Frailty is common among elderly colorectal cancer (CRC) patients and affects both perioperative and long-term outcomes. However, many aspects of how minimally invasive surgery (MIS) influences frailty remain unclear. Moreover, very few reports have specifically evaluated postoperative changes in frailty status.
[METHODS] In this prospective observational study, 239 CRC patients aged ≥ 70 years undergoing MIS with R0 resection were assessed for frailty using the FRAIL Scale and Kihon Checklist preoperatively and 1 year postoperatively. Short- and long-term oncological outcomes and frailty status changes were analyzed.
[RESULTS] A total of 88 patients (37%) were diagnosed as frail on the basis of either of the frailty assessment tools, and MIS was performed in all cases. Short-term outcomes were comparable between frail and non-frail patients; however, overall survival (OS) was significantly worse in frail patients (log-rank, = 0.01). Among the 141 patients who remained recurrence-free for 1 year and completed the second questionnaire, frailty status significantly improved according to the FRAIL Scale ( = 0.001). In patients whose frailty status improved, significant improvements in hemoglobin levels, the prognostic nutritional index, and psoas muscle index were observed compared with their preoperative values.
[CONCLUSIONS] Curative MIS was safely performed in elderly frail colorectal cancer patients without increasing perioperative complications; however, their long-term outcomes remained poor. Nevertheless, in patients who remained recurrence-free, frailty status significantly improved 1 year after surgery, suggesting an emerging potential benefit of surgical resection in the elderly population.
[METHODS] In this prospective observational study, 239 CRC patients aged ≥ 70 years undergoing MIS with R0 resection were assessed for frailty using the FRAIL Scale and Kihon Checklist preoperatively and 1 year postoperatively. Short- and long-term oncological outcomes and frailty status changes were analyzed.
[RESULTS] A total of 88 patients (37%) were diagnosed as frail on the basis of either of the frailty assessment tools, and MIS was performed in all cases. Short-term outcomes were comparable between frail and non-frail patients; however, overall survival (OS) was significantly worse in frail patients (log-rank, = 0.01). Among the 141 patients who remained recurrence-free for 1 year and completed the second questionnaire, frailty status significantly improved according to the FRAIL Scale ( = 0.001). In patients whose frailty status improved, significant improvements in hemoglobin levels, the prognostic nutritional index, and psoas muscle index were observed compared with their preoperative values.
[CONCLUSIONS] Curative MIS was safely performed in elderly frail colorectal cancer patients without increasing perioperative complications; however, their long-term outcomes remained poor. Nevertheless, in patients who remained recurrence-free, frailty status significantly improved 1 year after surgery, suggesting an emerging potential benefit of surgical resection in the elderly population.