Incidence of Gastrointestinal Adverse Events Following Left Hepatic Lobe Radiation Segmentectomy for the Treatment of Hepatocellular Carcinoma.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
18 patients who underwent subsequent liver transplantation or hepatectomy, increased surgical dissection time was documented in 6 (33%) patients secondary to presumed radiation-related adhesions.
I · Intervention 중재 / 시술
Yttrium-90-containing glass microsphere RS from 6/2017-9/2023 was performed
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSION] The incidence of severe GIAE following RS for HCC in the left hepatic lobe was low. Surgical adhesions after RS were common, but most did not increase surgical morbidity.
[PURPOSE] Describe the incidence and severity of gastrointestinal tract-related adverse events (GIAE) following radiation segmentectomy (RS) for hepatocellular carcinoma (HCC) in the left hepatic lobe
- 표본수 (n) 12
- 추적기간 931 days
APA
De La Garza-Ramos C, Silver C, et al. (2026). Incidence of Gastrointestinal Adverse Events Following Left Hepatic Lobe Radiation Segmentectomy for the Treatment of Hepatocellular Carcinoma.. Cardiovascular and interventional radiology. https://doi.org/10.1007/s00270-026-04376-9
MLA
De La Garza-Ramos C, et al.. "Incidence of Gastrointestinal Adverse Events Following Left Hepatic Lobe Radiation Segmentectomy for the Treatment of Hepatocellular Carcinoma.." Cardiovascular and interventional radiology, 2026.
PMID
41735654
Abstract
[PURPOSE] Describe the incidence and severity of gastrointestinal tract-related adverse events (GIAE) following radiation segmentectomy (RS) for hepatocellular carcinoma (HCC) in the left hepatic lobe.
[MATERIALS AND METHODS] A single-center retrospective analysis of patients with solitary, treatment-naïve, HCC in the left hepatic lobe who underwent Yttrium-90-containing glass microsphere RS from 6/2017-9/2023 was performed. Clinical, endoscopic apparent, and surgical GIAE up to last available follow-up were graded per the Common Terminology Criteria for Adverse Events. Tumor-to-GI tract distance and treatment parameters were evaluated for associations with GIAE.
[RESULTS] Forty-six patients with a median tumor size of 2.4 cm (IQR 2.1, 3.6) and median follow-up of 931 days (IQR 527, 1412) met inclusion criteria. Median treatment dose was 533 Gy (IQR 456, 853). Grade 1 GIAE were documented on 14 (30%) patients, including nausea/emesis (n = 12) and gastritis/duodenitis (n = 2). Grade 2 GIAE were documented in 2 (4%) patients with either multifocal gastric and duodenal ulcers or gastric erosions per endoscopy performed at a median of 53 days post-RS without histologic evidence of Yttrium-90 microspheres or radiation injury. In the 18 patients who underwent subsequent liver transplantation or hepatectomy, increased surgical dissection time was documented in 6 (33%) patients secondary to presumed radiation-related adhesions. Two surgical cases (11%) had grade 4 AE, which included intraoperative hemorrhage and duodenal avulsion. No significant association was found between GIAE and tumor-to-GI tract distance, dosimetry, or treatment parameters.
[CONCLUSION] The incidence of severe GIAE following RS for HCC in the left hepatic lobe was low. Surgical adhesions after RS were common, but most did not increase surgical morbidity.
[MATERIALS AND METHODS] A single-center retrospective analysis of patients with solitary, treatment-naïve, HCC in the left hepatic lobe who underwent Yttrium-90-containing glass microsphere RS from 6/2017-9/2023 was performed. Clinical, endoscopic apparent, and surgical GIAE up to last available follow-up were graded per the Common Terminology Criteria for Adverse Events. Tumor-to-GI tract distance and treatment parameters were evaluated for associations with GIAE.
[RESULTS] Forty-six patients with a median tumor size of 2.4 cm (IQR 2.1, 3.6) and median follow-up of 931 days (IQR 527, 1412) met inclusion criteria. Median treatment dose was 533 Gy (IQR 456, 853). Grade 1 GIAE were documented on 14 (30%) patients, including nausea/emesis (n = 12) and gastritis/duodenitis (n = 2). Grade 2 GIAE were documented in 2 (4%) patients with either multifocal gastric and duodenal ulcers or gastric erosions per endoscopy performed at a median of 53 days post-RS without histologic evidence of Yttrium-90 microspheres or radiation injury. In the 18 patients who underwent subsequent liver transplantation or hepatectomy, increased surgical dissection time was documented in 6 (33%) patients secondary to presumed radiation-related adhesions. Two surgical cases (11%) had grade 4 AE, which included intraoperative hemorrhage and duodenal avulsion. No significant association was found between GIAE and tumor-to-GI tract distance, dosimetry, or treatment parameters.
[CONCLUSION] The incidence of severe GIAE following RS for HCC in the left hepatic lobe was low. Surgical adhesions after RS were common, but most did not increase surgical morbidity.