ꞵ-CuVO/Cs NIR (II) responsive nanocomposite for synergistic chemodynamic/photothermal therapy with multi-modal imaging in hepatocellular carcinoma.
1/5 보강
Developing nanomedicine with dual therapeutic and imaging capabilities is a challenging endeavor.
APA
Muthiah KS, Natarajan SR, et al. (2026). ꞵ-CuVO/Cs NIR (II) responsive nanocomposite for synergistic chemodynamic/photothermal therapy with multi-modal imaging in hepatocellular carcinoma.. Biomaterials advances, 180, 214602. https://doi.org/10.1016/j.bioadv.2025.214602
MLA
Muthiah KS, et al.. "ꞵ-CuVO/Cs NIR (II) responsive nanocomposite for synergistic chemodynamic/photothermal therapy with multi-modal imaging in hepatocellular carcinoma.." Biomaterials advances, vol. 180, 2026, pp. 214602.
PMID
41253029 ↗
Abstract 한글 요약
Developing nanomedicine with dual therapeutic and imaging capabilities is a challenging endeavor. In this study, copper vanadate nanosheets modified with carbon nanospheres (β-Cu₂V₂O₇/Cs NCs) nanocomposites were synthesized using a simple hydrothermal method. These NCs effectively combine chemodynamic therapy (CDT) and photothermal therapy (PTT), addressing the limitations of single treatments and enhancing antitumor effects. The synthesized NCs generate cytotoxic reactive oxygen species (•OH) via the Fenton reaction with overexpressed H₂O₂ in the tumor microenvironment. At the same time, Cs absorb near-infrared (NIR) light, causing a localized temperature rise for PTT. Additionally, copper (Cu) is an MRI and CT imaging agent due to its low toxicity and biocompatibility. The NCs achieved a photothermal conversion efficiency (ꞃ) of 59.5 % and demonstrated high antitumor efficacy, killing 80 % of HepG-2 cells in vitro through G1 phase cell cycle arrest and metabolic reprogramming. In vivo, the tumor inhibition rate (TGI) reached 95 % with no observable toxicity, confirmed by staining analysis. This study highlights a versatile and biocompatible nano platform for synergistic cancer therapy and multimodal imaging applications.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Nanocomposites
- Copper
- Animals
- Liver Neoplasms
- Carcinoma
- Hepatocellular
- Hep G2 Cells
- Photothermal Therapy
- Mice
- Infrared Rays
- Vanadates
- Inbred BALB C
- Magnetic Resonance Imaging
- Multimodal Imaging
- Carbon
- Carbon nanospheres
- Chemodynamic therapy
- Copper vanadate nanosheets
- Photothermal conversion efficiency
- Photothermal therapy
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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