Adaptive plasticity in targeted therapy.
1/5 보강
In this issue of Cancer Cell, Zhang et al.
APA
Amodio V, Patelli G, Bardelli A (2026). Adaptive plasticity in targeted therapy.. Cancer cell, 44(1), 15-17. https://doi.org/10.1016/j.ccell.2025.12.007
MLA
Amodio V, et al.. "Adaptive plasticity in targeted therapy.." Cancer cell, vol. 44, no. 1, 2026, pp. 15-17.
PMID
41478275 ↗
Abstract 한글 요약
In this issue of Cancer Cell, Zhang et al. show that dual KRAS-EGFR inhibition induces a reversible Paneth-like transition in colorectal cancer, sustaining mitogen-activated protein kinase (MAPK) reactivation through a SMAD1-FGFR3 axis. This reinforces emerging evidence that lineage remodeling underlies early adaptive escape from targeted therapy and carries potential clinical relevance.
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