Prognostic significance of DNA ploidy, stroma fraction, and nucleotyping in stage IIIb colon cancer and their implications for adjuvant chemotherapy.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
radical surgery and postoperative adjuvant chemotherapy at Sun Yat-sen University Cancer Center were retrospectively collected
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
87.05%, P = 0.598). [CONCLUSION] The PSN panel effectively stratifies stage IIIb colon cancer, aiding in optimized adjuvant chemotherapy duration determination.
[BACKGROUND] DNA ploidy (P), stroma fraction (S), and nucleotyping (N), collectively known as PSN, have demonstrated prognostic accuracy in various stages of colorectal cancer (CRC).
- p-value P = 0.023
- p-value P = 0.003
- 95% CI 1.616-10.742
- HR 4.166
APA
Zhang W, Gu Y, et al. (2026). Prognostic significance of DNA ploidy, stroma fraction, and nucleotyping in stage IIIb colon cancer and their implications for adjuvant chemotherapy.. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 28(2), 625-634. https://doi.org/10.1007/s12094-025-04029-2
MLA
Zhang W, et al.. "Prognostic significance of DNA ploidy, stroma fraction, and nucleotyping in stage IIIb colon cancer and their implications for adjuvant chemotherapy.." Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, vol. 28, no. 2, 2026, pp. 625-634.
PMID
40841502
Abstract
[BACKGROUND] DNA ploidy (P), stroma fraction (S), and nucleotyping (N), collectively known as PSN, have demonstrated prognostic accuracy in various stages of colorectal cancer (CRC). However, the prognostic value of the PSN panel in stage IIIb colon cancer patients receiving CapOX adjuvant chemotherapy remains unclear.
[PATIENTS AND METHODS] Postoperative pathological samples from stage IIIb colon cancer patients who underwent radical surgery and postoperative adjuvant chemotherapy at Sun Yat-sen University Cancer Center were retrospectively collected. Kaplan-Meier and Cox regression were performed to compare survival among subgroups of patients stratified by PSN, in order to elucidate the benefits of different durations of adjuvant CapOX chemotherapy.
[RESULT] The PSN low-risk group had the highest 5-year DFS (95.77% vs. 83.07% vs. 84.29%, P = 0.023). Multivariate Cox regression analysis identified primary tumor location (HR = 4.166, 95% CI 1.616-10.742, P = 0.003), perineural invasion (HR = 2.358, 95% CI 1.205-4.615, P = 0.012), and PSN high risk (HR = 3.830, 95% CI 1.352-10.853, P = 0.011) as independent predictors of DFS. No significant difference in 5-year DFS and overall survival (OS) was observed between patients receiving 4-7 cycles and those receiving 8 cycles of CapOX (DFS: 86.24% vs. 88.77%, P = 0.082; OS: 96.38% vs. 94.23%, P = 0.088). However, in the PSN high-risk group, completing 8 cycles of CapOX significantly improved 5-year DFS and OS compared to 4-7 cycles (DFS: 93.10% vs. 77.04%, P = 0.033; OS: 96.30% vs. 91.24%, P = 0.037). In contrast, no significant difference in DFS was observed in the IDEA (International Duration Evaluation of Adjuvant therapy)-based high-risk group (DFS: 85.85% vs. 80.75%, P = 0.062; OS: 97.56% vs. 87.05%, P = 0.598).
[CONCLUSION] The PSN panel effectively stratifies stage IIIb colon cancer, aiding in optimized adjuvant chemotherapy duration determination.
[PATIENTS AND METHODS] Postoperative pathological samples from stage IIIb colon cancer patients who underwent radical surgery and postoperative adjuvant chemotherapy at Sun Yat-sen University Cancer Center were retrospectively collected. Kaplan-Meier and Cox regression were performed to compare survival among subgroups of patients stratified by PSN, in order to elucidate the benefits of different durations of adjuvant CapOX chemotherapy.
[RESULT] The PSN low-risk group had the highest 5-year DFS (95.77% vs. 83.07% vs. 84.29%, P = 0.023). Multivariate Cox regression analysis identified primary tumor location (HR = 4.166, 95% CI 1.616-10.742, P = 0.003), perineural invasion (HR = 2.358, 95% CI 1.205-4.615, P = 0.012), and PSN high risk (HR = 3.830, 95% CI 1.352-10.853, P = 0.011) as independent predictors of DFS. No significant difference in 5-year DFS and overall survival (OS) was observed between patients receiving 4-7 cycles and those receiving 8 cycles of CapOX (DFS: 86.24% vs. 88.77%, P = 0.082; OS: 96.38% vs. 94.23%, P = 0.088). However, in the PSN high-risk group, completing 8 cycles of CapOX significantly improved 5-year DFS and OS compared to 4-7 cycles (DFS: 93.10% vs. 77.04%, P = 0.033; OS: 96.30% vs. 91.24%, P = 0.037). In contrast, no significant difference in DFS was observed in the IDEA (International Duration Evaluation of Adjuvant therapy)-based high-risk group (DFS: 85.85% vs. 80.75%, P = 0.062; OS: 97.56% vs. 87.05%, P = 0.598).
[CONCLUSION] The PSN panel effectively stratifies stage IIIb colon cancer, aiding in optimized adjuvant chemotherapy duration determination.
MeSH Terms
Humans; Female; Chemotherapy, Adjuvant; Male; Colonic Neoplasms; Middle Aged; Prognosis; Retrospective Studies; Aged; Ploidies; Neoplasm Staging; Antineoplastic Combined Chemotherapy Protocols; Adult; Oxaliplatin; Cyclophosphamide; Stromal Cells; Survival Rate; DNA, Neoplasm
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