Diagnosing HCC with conventional and late portal venous phase MRI: intraindividual comparison of MRI with extracellular contrast agent.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
both ECA-MRI and EOB-MRI using CPVP and LPVP
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Findings EOB-MRI using LPVP improved the sensitivity of HCC diagnoses compared with ECA-MRI and EOB-MRI using conventional portal venous phase, without compromising specificity. Clinical relevance EOB-MRI using LPVP may be a suitable option for HCC diagnosis, demonstrating higher sensitivity than ECA-MRI without compromising specificity.
[OBJECTIVES] To evaluate the diagnostic performance of MRI with gadoxetate disodium (EOB-MRI) using conventional portal venous phase (CPVP) and late portal venous phase (LPVP) in the noninvasive diagn
- p-value p = 0.02
APA
Jeong B, Han DH, et al. (2026). Diagnosing HCC with conventional and late portal venous phase MRI: intraindividual comparison of MRI with extracellular contrast agent.. European radiology, 36(4), 2903-2911. https://doi.org/10.1007/s00330-025-12082-2
MLA
Jeong B, et al.. "Diagnosing HCC with conventional and late portal venous phase MRI: intraindividual comparison of MRI with extracellular contrast agent.." European radiology, vol. 36, no. 4, 2026, pp. 2903-2911.
PMID
41136757 ↗
Abstract 한글 요약
[OBJECTIVES] To evaluate the diagnostic performance of MRI with gadoxetate disodium (EOB-MRI) using conventional portal venous phase (CPVP) and late portal venous phase (LPVP) in the noninvasive diagnosis of hepatocellular carcinoma (HCC), with intraindividual comparison of MRI with extracellular contrast agent (ECA-MRI).
[MATERIALS AND METHODS] This retrospective study included 107 prospectively enrolled at-risk patients (mean age, 59.4 years; 89 men) with 143 lesions (118 HCCs) who underwent both ECA-MRI and EOB-MRI using CPVP and LPVP. Two radiologists assessed all lesions using LI-RADS v2018. The per-lesion diagnostic performance was compared using generalized estimating equations.
[RESULTS] In HCCs, nonperipheral washout appearance was less frequent on EOB-MRI using CPVP than on ECA-MRI (R1: 69.5 vs. 79.7%, p = 0.02; R2: 66.9 vs. 76.3%, p = 0.02), but more frequent on EOB-MRI using LPVP than on ECA-MRI (R1: 94.1 vs. 79.7%, p < 0.001; R2: 92.4 vs. 76.3%, p < 0.001). For LR-5, EOB-MRI using LPVP showed significantly higher sensitivity for diagnosing HCC than ECA-MRI (R1, 80.5 vs. 72.0%, p = 0.03; R2: 79.7 vs. 71.2%, p = 0.01), while EOB-MRI using CPVP showed significantly lower sensitivity than ECA-MRI (R1: 64.4 vs. 72.0%, p = 0.03; R2: 64.4 vs. 71.2%, p = 0.03). The specificity of EOB-MRI using LPVP (both Readers: 88.0%) did not differ significantly from that of ECA-MRI (both Readers: 92.0%, p = 0.31) or EOB-MRI using CPVP (both Readers: 92.0%, p = 0.31).
[CONCLUSIONS] EOB-MRI using LPVP demonstrated higher sensitivity for HCC diagnosis than ECA-MRI and EOB-MRI using CPVP, while maintaining comparable specificity.
[KEY POINTS] Question MRI with gadoxetate disodium (EOB-MRI) using the late portal venous phase (LPVP) for HCC diagnosis has not been directly compared with MRI with extracellular contrast agent (ECA-MRI). Findings EOB-MRI using LPVP improved the sensitivity of HCC diagnoses compared with ECA-MRI and EOB-MRI using conventional portal venous phase, without compromising specificity. Clinical relevance EOB-MRI using LPVP may be a suitable option for HCC diagnosis, demonstrating higher sensitivity than ECA-MRI without compromising specificity.
[MATERIALS AND METHODS] This retrospective study included 107 prospectively enrolled at-risk patients (mean age, 59.4 years; 89 men) with 143 lesions (118 HCCs) who underwent both ECA-MRI and EOB-MRI using CPVP and LPVP. Two radiologists assessed all lesions using LI-RADS v2018. The per-lesion diagnostic performance was compared using generalized estimating equations.
[RESULTS] In HCCs, nonperipheral washout appearance was less frequent on EOB-MRI using CPVP than on ECA-MRI (R1: 69.5 vs. 79.7%, p = 0.02; R2: 66.9 vs. 76.3%, p = 0.02), but more frequent on EOB-MRI using LPVP than on ECA-MRI (R1: 94.1 vs. 79.7%, p < 0.001; R2: 92.4 vs. 76.3%, p < 0.001). For LR-5, EOB-MRI using LPVP showed significantly higher sensitivity for diagnosing HCC than ECA-MRI (R1, 80.5 vs. 72.0%, p = 0.03; R2: 79.7 vs. 71.2%, p = 0.01), while EOB-MRI using CPVP showed significantly lower sensitivity than ECA-MRI (R1: 64.4 vs. 72.0%, p = 0.03; R2: 64.4 vs. 71.2%, p = 0.03). The specificity of EOB-MRI using LPVP (both Readers: 88.0%) did not differ significantly from that of ECA-MRI (both Readers: 92.0%, p = 0.31) or EOB-MRI using CPVP (both Readers: 92.0%, p = 0.31).
[CONCLUSIONS] EOB-MRI using LPVP demonstrated higher sensitivity for HCC diagnosis than ECA-MRI and EOB-MRI using CPVP, while maintaining comparable specificity.
[KEY POINTS] Question MRI with gadoxetate disodium (EOB-MRI) using the late portal venous phase (LPVP) for HCC diagnosis has not been directly compared with MRI with extracellular contrast agent (ECA-MRI). Findings EOB-MRI using LPVP improved the sensitivity of HCC diagnoses compared with ECA-MRI and EOB-MRI using conventional portal venous phase, without compromising specificity. Clinical relevance EOB-MRI using LPVP may be a suitable option for HCC diagnosis, demonstrating higher sensitivity than ECA-MRI without compromising specificity.
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