Noncanonical EZH2 activity cooperates with FOXM1 to drive tumorigenesis and advanced progression in HCC.
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TL;DR
These findings extend the understanding of EZH2 biology beyond its canonical epigenetic function and uncover a druggable vulnerability in aggressive HCC, and Targeting the EZH2–FOXM1 axis may provide a mechanistically grounded strategy to inhibit HCC proliferation and progression.
OpenAlex 토픽 ·
FOXO transcription factor regulation
Cancer, Hypoxia, and Metabolism
Histone Deacetylase Inhibitors Research
These findings extend the understanding of EZH2 biology beyond its canonical epigenetic function and uncover a druggable vulnerability in aggressive HCC, and Targeting the EZH2–FOXM1 axis may provide
APA
Sungju Jung, Hyun Jin Bang, et al. (2026). Noncanonical EZH2 activity cooperates with FOXM1 to drive tumorigenesis and advanced progression in HCC.. Clinical and molecular hepatology, 32(2), e179-e184. https://doi.org/10.3350/cmh.2025.1379
MLA
Sungju Jung, et al.. "Noncanonical EZH2 activity cooperates with FOXM1 to drive tumorigenesis and advanced progression in HCC.." Clinical and molecular hepatology, vol. 32, no. 2, 2026, pp. e179-e184.
PMID
41622630 ↗
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