Rethinking the role of endoscopy for colorectal cancer following diverticulitis: An exploratory model for guiding endoscopic assessment.
[BACKGROUND] The association between diverticulitis and colorectal (CRC) remains controversial, with current guidelines differing significantly in terms of post-diverticulitis endoscopic assessment.
- p-value p < 0.001
- 95% CI 1.14-1.45
- 연구 설계 cohort study
APA
Usman M, Correa E, et al. (2026). Rethinking the role of endoscopy for colorectal cancer following diverticulitis: An exploratory model for guiding endoscopic assessment.. The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland. https://doi.org/10.1016/j.surge.2026.01.002
MLA
Usman M, et al.. "Rethinking the role of endoscopy for colorectal cancer following diverticulitis: An exploratory model for guiding endoscopic assessment.." The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, 2026.
PMID
41633884
Abstract
[BACKGROUND] The association between diverticulitis and colorectal (CRC) remains controversial, with current guidelines differing significantly in terms of post-diverticulitis endoscopic assessment. This study is aimed at developing an exploratory model to identify patients at high risk of CRC following diverticulitis.
[METHODS] This retrospective cohort study analyzed 1546 patients diagnosed with diverticulitis between January 2021 and December 2023 at a UK tertiary care hospital. Ordinal logistic regression was used to identify predictors associated with CRC risk.
[RESULTS] Of 1546 patients, the mean age was 69.2 years SD ± 12.9, and 51.5 % were female. Increasing age (OR 1.28 per SD, 95 % CI 1.14-1.45, p < 0.001) and male sex (OR 1.75, 95 % CI 1.39-2.21, p < 0.001) were high risk predictors associated with increased risk of CRC. Conversely, abdominal pain (OR 0.60, 95 % CI 0.44-0.80, p = 0.001) and per-rectal bleeding (OR 0.71, 95 % CI 0.56-0.89, p = 0.004), and presence of diverticulosis showed a protective association (OR 0.68, 95 % CI 0.47-0.97, p = 0.033), which could be due to confounding. CT findings did not achieve statistical significance as independent predictors in the multivariable model.
[CONCLUSIONS] This exploratory model identifies patient characteristics that stratify CRC risk following diverticulitis. These findings may help personalize decisions regarding post-diverticulitis colonoscopy, optimizing resource allocation while maintaining appropriate cancer surveillance. However, this model would require external validation before use in clinical practice.
[METHODS] This retrospective cohort study analyzed 1546 patients diagnosed with diverticulitis between January 2021 and December 2023 at a UK tertiary care hospital. Ordinal logistic regression was used to identify predictors associated with CRC risk.
[RESULTS] Of 1546 patients, the mean age was 69.2 years SD ± 12.9, and 51.5 % were female. Increasing age (OR 1.28 per SD, 95 % CI 1.14-1.45, p < 0.001) and male sex (OR 1.75, 95 % CI 1.39-2.21, p < 0.001) were high risk predictors associated with increased risk of CRC. Conversely, abdominal pain (OR 0.60, 95 % CI 0.44-0.80, p = 0.001) and per-rectal bleeding (OR 0.71, 95 % CI 0.56-0.89, p = 0.004), and presence of diverticulosis showed a protective association (OR 0.68, 95 % CI 0.47-0.97, p = 0.033), which could be due to confounding. CT findings did not achieve statistical significance as independent predictors in the multivariable model.
[CONCLUSIONS] This exploratory model identifies patient characteristics that stratify CRC risk following diverticulitis. These findings may help personalize decisions regarding post-diverticulitis colonoscopy, optimizing resource allocation while maintaining appropriate cancer surveillance. However, this model would require external validation before use in clinical practice.