A snapshot of the earliest stages of hepatocellular carcinoma.

Andrades Á; Korbel JO

doi:10.1016/j.ccell.2026.03.008

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A snapshot of the earliest stages of hepatocellular carcinoma.

Cancer cell 2026

Andrades Á, Korbel JO

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How premalignant tissue transforms into cancer remains an open question.

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BibTeX ↓ RIS ↓

APA Andrades Á, Korbel JO (2026). A snapshot of the earliest stages of hepatocellular carcinoma.. Cancer cell. https://doi.org/10.1016/j.ccell.2026.03.008

MLA Andrades Á, et al.. "A snapshot of the earliest stages of hepatocellular carcinoma.." Cancer cell, 2026.

PMID 41932330

DOI 10.1016/j.ccell.2026.03.008

Abstract

How premalignant tissue transforms into cancer remains an open question. In this issue of Cancer Cell, Zhang et al. address this by comparing early hepatocellular carcinomas with matched premalignant tissue, revealing potential paths for malignant transformation: one characterized by high copy-number alteration burden and one characterized by high inflammation.