The impact of the microbiome on colorectal cancer recurrence after resection.
1/5 보강
Surgical resection of a colorectal adenocarcinoma remains a cornerstone in its treatment.
APA
Suss NR, Barat B, et al. (2026). The impact of the microbiome on colorectal cancer recurrence after resection.. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 102360. https://doi.org/10.1016/j.gassur.2026.102360
MLA
Suss NR, et al.. "The impact of the microbiome on colorectal cancer recurrence after resection.." Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2026, pp. 102360.
PMID
41651403 ↗
Abstract 한글 요약
Surgical resection of a colorectal adenocarcinoma remains a cornerstone in its treatment. However, despite proper patient selection and neoadjuvant and/or adjuvant chemotherapy/radiation, up to 30% of patients thought to be cured will develop a postoperative recurrence. Unfortunately, the outcomes in patients who develop a postoperative recurrence are poor and are associated with high morbidity and mortality. The gut microbiome has emerged to play a role in virtually all aspects of human health. In this manuscript, we critically examine the current literature implicating the gut microbiome's role in the pathogenesis of postoperative recurrence after attempted curative resection. We discuss how microbes can drive a more advanced stage and explore how surgery itself can precipitate a gut microenvironment with tumorigenic bacteria and bacterial-derived metabolites that can drive postoperative tumor formation. Finally, we review evidence as to how the gut microbiome can be manipulated to improve oncological outcomes.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- Opposing prognostic roles of tumor-associated and circulating MMP8 in colorectal cancer.
- Copper-enriched zinc peroxides induced cuproptosis through concurrent metabolic and oxidative dysregulation for boosting immunotherapy in colorectal cancer.
- Editorial: Altered metabolic traits in gastro-intestinal tract cancers, volume II.
- Macrophage deficiency discordantly regulated tumor growth and metastasis through increased thrombospondin-1 production.
- Time-Resolved Oxygen Dynamics Reveals Redox-Selective Apoptosis Induced by Cold Atmospheric Plasma in HT-29 Colorectal Cancer Cells.
- System-Wide Implementation of Colorectal Cancer Screening in a Value-Based Care Setting.