Enantioselective reductive cyclization of alkynals cobalt catalysis.
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Catalytic C–H Functionalization Methods
Radical Photochemical Reactions
Asymmetric Hydrogenation and Catalysis
Transition metal-catalyzed asymmetric intermolecular reductive coupling of alkynes and aldehydes has been well-established for constructing chiral allylic alcohols.
APA
Jing-Jing Zhu, Min-Min Liu, et al. (2026). Enantioselective reductive cyclization of alkynals cobalt catalysis.. Chemical communications (Cambridge, England), 62(28), 7399-7403. https://doi.org/10.1039/d6cc00805d
MLA
Jing-Jing Zhu, et al.. "Enantioselective reductive cyclization of alkynals cobalt catalysis.." Chemical communications (Cambridge, England), vol. 62, no. 28, 2026, pp. 7399-7403.
PMID
41885509
Abstract
Transition metal-catalyzed asymmetric intermolecular reductive coupling of alkynes and aldehydes has been well-established for constructing chiral allylic alcohols. In contrast, the intramolecular variant remains underexplored. Herein, we present a cobalt-catalyzed reductive cyclization of alkynals, providing chiral 4-chromanols with high efficiency (83% average yield), good to excellent enantioselectivities (85-96% ee), and broad functional group tolerance. Moreover, preliminary bioactivity studies against human hepatocellular carcinoma cells have also been performed.