Thorough analysis of tumor microenvironment, prognostic model, and immunotherapy prediction in hepatocellular carcinoma based on vascular normalization-related genes.
2/5 보강
OpenAlex 토픽 ·
Hepatocellular Carcinoma Treatment and Prognosis
Ferroptosis and cancer prognosis
Angiogenesis and VEGF in Cancer
Hepatocellular carcinoma (HCC) ranks sixth in incidence and third in mortality worldwide.
APA
Y Hu, Mingwei Zeng, et al. (2026). Thorough analysis of tumor microenvironment, prognostic model, and immunotherapy prediction in hepatocellular carcinoma based on vascular normalization-related genes.. Computer methods in biomechanics and biomedical engineering, 1-17. https://doi.org/10.1080/10255842.2026.2656292
MLA
Y Hu, et al.. "Thorough analysis of tumor microenvironment, prognostic model, and immunotherapy prediction in hepatocellular carcinoma based on vascular normalization-related genes.." Computer methods in biomechanics and biomedical engineering, 2026, pp. 1-17.
PMID
41989335 ↗
Abstract 한글 요약
Hepatocellular carcinoma (HCC) ranks sixth in incidence and third in mortality worldwide. Immunotherapy for advanced HCC is limited by drug resistance. Vascular normalization (VN) restores tumor neovasculature, alleviates immunosuppression, and enhances immunotherapy. However, roles of VN-related genes (VNRGs) in HCC remain understudied. In this study, bioinformatics methods explored roles and constructed a prognostic model. The VNRGs-high expression group had higher immune infiltration, lower tumor purity and worse outcomes. An eight-VNRG prognostic model was constructed. High-risk patients had poor outcomes but better immunotherapy response. This study highlights VNRGs' significance and shows the risk score function as a prognostic and immune response indicator.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
같은 제1저자의 인용 많은 논문 (5)
- Supramastoid Fascia as an Autologous Donor Site Alternative for Moderate Dorsal Augmentation: A Multicenter Prospective Study.
- ICAP-1 alternative splicing regulates Talin tension polarization in NSCLC durotaxis.
- Chemotherapy combined with pembrolizumab in advanced gallbladder cancer with subsequent radical resection: A case report.
- Fgfr4 combined with inflammatory cytokines improves recurrence risk prediction in differentiated thyroid carcinoma: A retrospective cohort study.
- Pretreatment multiphasic contrast-enhanced CT predicts tumor regression grade and survival in locally advanced gastric cancer.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- Raman Spectroscopic Signatures of Hepatic Carcinoma: Progress and Future Prospect.
- Heat Shock Protein 47 as a Novel Predictive and Diagnostic Biomarker for Thrombosis in Hepatocellular Carcinoma.
- Crosstalk Between -Regulatory Elements and Metabolism Reprogramming in Hepatocellular Carcinoma.
- TAZ WW Domain-Mediated Regulation of Gluconeogenesis and Tumorigenesis in Hepatocellular Carcinoma through Interaction with the Glucocorticoid Receptor.
- Enhanced efficacy and long-term survival with SBRT plus PD-1 inhibitors versus SBRT alone in unresectable HCC: a multicenter PSM study.
- Risks, Benefits, and Molecular Targets of Fenugreek Administration in the Treatment of Hepatocellular Carcinoma.