ZFP161 promotes colorectal cancer progression by transcriptionally activating c-MYC.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: mixed colon adenocarcinoma
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Furthermore, high expression is associated with poor survival in patients with mixed colon adenocarcinoma. These findings suggest that the regulation of by ZFP161 may represent a potential therapeutic target in -driven cancers.
Zinc Finger Protein 161 (ZFP161) is a key regulator of Ataxia Telangiectasia and Rad3-related (ATR) signaling, playing a crucial role in maintaining genomic stability.
APA
Christyani G, Cai C, et al. (2025). ZFP161 promotes colorectal cancer progression by transcriptionally activating c-MYC.. Frontiers in oncology, 15, 1680561. https://doi.org/10.3389/fonc.2025.1680561
MLA
Christyani G, et al.. "ZFP161 promotes colorectal cancer progression by transcriptionally activating c-MYC.." Frontiers in oncology, vol. 15, 2025, pp. 1680561.
PMID
41789397 ↗
Abstract 한글 요약
Zinc Finger Protein 161 (ZFP161) is a key regulator of Ataxia Telangiectasia and Rad3-related (ATR) signaling, playing a crucial role in maintaining genomic stability. Human ZFP161 activates , whereas its murine ortholog, ZF5, serves as a putative transcriptional repressor of . In this study, we identified ZFP161 as a direct regulator of c-MYC. We show that ZFP161 binds to the promoter region of , modulating its expression and downstream signaling pathways. Additionally, ZFP161 promotes cell proliferation and tumorigenesis through c-MYC regulation and contributes to the malignant transformation of non-cancerous retinal pigment epithelial (RPE-1) cells. Furthermore, high expression is associated with poor survival in patients with mixed colon adenocarcinoma. These findings suggest that the regulation of by ZFP161 may represent a potential therapeutic target in -driven cancers.
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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