Peripheral blood immune cell subsets as non-invasive biomarkers of colorectal cancer stage, laterality, metastasis and survival.
1/5 보강
[PURPOSE] Colorectal cancer (CRC) is a heterogeneous disease in which immune dynamics critically influence tumour progression and patient outcomes; however, the relationship between circulating immune
APA
Del Prado-Montero J, Cantero-Cid R, et al. (2026). Peripheral blood immune cell subsets as non-invasive biomarkers of colorectal cancer stage, laterality, metastasis and survival.. Cellular oncology (Dordrecht, Netherlands), 49(2). https://doi.org/10.1007/s13402-026-01174-w
MLA
Del Prado-Montero J, et al.. "Peripheral blood immune cell subsets as non-invasive biomarkers of colorectal cancer stage, laterality, metastasis and survival.." Cellular oncology (Dordrecht, Netherlands), vol. 49, no. 2, 2026.
PMID
41733817 ↗
Abstract 한글 요약
[PURPOSE] Colorectal cancer (CRC) is a heterogeneous disease in which immune dynamics critically influence tumour progression and patient outcomes; however, the relationship between circulating immune cell subsets, immune checkpoints (ICs) expression, and clinical parameters remains poorly defined.
[METHODS] In this study, we employed a high-dimensional spectral flow cytometry approach to analyse peripheral whole blood samples from 16 CRC patients, profiling 918 immune populations across both innate and adaptive compartments. Immune profiles were stratified by tumour stage (I vs. II–III), anatomical location (colon vs. rectum; right- vs. left-sided), and three-year metastasis and survival outcomes. Data analysis included unsupervised clustering, multiple t-tests, volcano plots, ROC curve analysis and logistic regression models.
[RESULTS] Preliminary patterns suggested associations between specific immune populations and clinical features: locally advanced-stage disease (stages II and III) tended to show higher frequencies of CD134CD4 conventional T cells and CCR6- CD161CD57-CD8natural killer T cells; rectal tumours were appeared enriched in regulatory T cells and basophils, and right- and left-sided colon cancers exhibited divergent CD4+CD8+ T cell distributions. Metastatic patients displayed an abundance of CD152 CD14 monocytes. Mortality correlated with the presence of CD141 CD1c myeloid dendritic cells and CD4CD8 Conventional T cells.
[CONCLUSION] All immune signatures demonstrated perfect classification, with an area under the curve (AUC) value of 1.000. Despite the limited size of the cohort, these findings provide preliminary evidence for the potential of peripheral immune profiling as a non-invasive approach for prognostication and patient stratification in CRC.
[SUPPLEMENTARY INFORMATION] The online version contains supplementary material available at 10.1007/s13402-026-01174-w.
[METHODS] In this study, we employed a high-dimensional spectral flow cytometry approach to analyse peripheral whole blood samples from 16 CRC patients, profiling 918 immune populations across both innate and adaptive compartments. Immune profiles were stratified by tumour stage (I vs. II–III), anatomical location (colon vs. rectum; right- vs. left-sided), and three-year metastasis and survival outcomes. Data analysis included unsupervised clustering, multiple t-tests, volcano plots, ROC curve analysis and logistic regression models.
[RESULTS] Preliminary patterns suggested associations between specific immune populations and clinical features: locally advanced-stage disease (stages II and III) tended to show higher frequencies of CD134CD4 conventional T cells and CCR6- CD161CD57-CD8natural killer T cells; rectal tumours were appeared enriched in regulatory T cells and basophils, and right- and left-sided colon cancers exhibited divergent CD4+CD8+ T cell distributions. Metastatic patients displayed an abundance of CD152 CD14 monocytes. Mortality correlated with the presence of CD141 CD1c myeloid dendritic cells and CD4CD8 Conventional T cells.
[CONCLUSION] All immune signatures demonstrated perfect classification, with an area under the curve (AUC) value of 1.000. Despite the limited size of the cohort, these findings provide preliminary evidence for the potential of peripheral immune profiling as a non-invasive approach for prognostication and patient stratification in CRC.
[SUPPLEMENTARY INFORMATION] The online version contains supplementary material available at 10.1007/s13402-026-01174-w.
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