Occupational exposure to endocrine-disrupting chemicals and colorectal cancer risk - An analysis of four participating cohorts of the Canadian Partnership for Tomorrow's Health study.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
4788 participants was selected at baseline.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSION] We observed some associations between occupational EDC exposure and colorectal cancer risk. Further investigation of these relationships is warranted.
[INTRODUCTION] Endocrine-disrupting chemicals (EDCs) may influence cancer risk by interfering with sex hormone balance.
- 95% CI 1.01-1.70
- OR 1.31
- 연구 설계 cohort study
APA
Pelland-St-Pierre L, Siemiatycki J, et al. (2026). Occupational exposure to endocrine-disrupting chemicals and colorectal cancer risk - An analysis of four participating cohorts of the Canadian Partnership for Tomorrow's Health study.. Environmental research, 299, 124299. https://doi.org/10.1016/j.envres.2026.124299
MLA
Pelland-St-Pierre L, et al.. "Occupational exposure to endocrine-disrupting chemicals and colorectal cancer risk - An analysis of four participating cohorts of the Canadian Partnership for Tomorrow's Health study.." Environmental research, vol. 299, 2026, pp. 124299.
PMID
41856231
Abstract
[INTRODUCTION] Endocrine-disrupting chemicals (EDCs) may influence cancer risk by interfering with sex hormone balance. Yet, the role of EDCs in colorectal cancer remains underexplored. EDC exposure is common in the environment, but levels are much higher in certain workplaces. This study assessed the association between occupational exposure to selected EDCs and colorectal cancer risk.
[METHODS] A case-cohort study was nested within four regional cohorts of the Canadian Partnership for Tomorrow's Health study. Cases included 1083 incident colorectal cancer cases, and a subcohort of 4788 participants was selected at baseline. Occupational exposure to 17 EDCs in participants' longest-held job was estimated using CANJEM, a job exposure matrix, which provided the probability of exposure for each EDC-job combination. Participants were categorized into unexposed (probability = 0), possibly exposed (0<probability<25%) or exposed (probability≥25%) for each EDC. Exposure was conceptualized in three ways: any exposure, grouped by mode of action (estrogenic, antiestrogenic, and antiandrogenic), and individual EDCs. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated between EDC exposure and colorectal cancer in each regional cohort and pooled using fixed-effect models.
[RESULTS] Compared to unexposed participants, participants exposed to antiestrogenic EDCs had an elevated colorectal cancer risk (OR = 1.31, 95%CI: 1.01-1.70). Risk was increased for possible exposure to arsenic (OR = 1.67, 95%CI: 1.27-2.21) and polychlorinated biphenyls (OR = 3.34, 95%CI: 2.20-5.07). Participants possibly exposed to cadmium (OR = 0.78, 95%CI: 0.63-0.96) had a lower colorectal cancer risk.
[CONCLUSION] We observed some associations between occupational EDC exposure and colorectal cancer risk. Further investigation of these relationships is warranted.
[METHODS] A case-cohort study was nested within four regional cohorts of the Canadian Partnership for Tomorrow's Health study. Cases included 1083 incident colorectal cancer cases, and a subcohort of 4788 participants was selected at baseline. Occupational exposure to 17 EDCs in participants' longest-held job was estimated using CANJEM, a job exposure matrix, which provided the probability of exposure for each EDC-job combination. Participants were categorized into unexposed (probability = 0), possibly exposed (0<probability<25%) or exposed (probability≥25%) for each EDC. Exposure was conceptualized in three ways: any exposure, grouped by mode of action (estrogenic, antiestrogenic, and antiandrogenic), and individual EDCs. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated between EDC exposure and colorectal cancer in each regional cohort and pooled using fixed-effect models.
[RESULTS] Compared to unexposed participants, participants exposed to antiestrogenic EDCs had an elevated colorectal cancer risk (OR = 1.31, 95%CI: 1.01-1.70). Risk was increased for possible exposure to arsenic (OR = 1.67, 95%CI: 1.27-2.21) and polychlorinated biphenyls (OR = 3.34, 95%CI: 2.20-5.07). Participants possibly exposed to cadmium (OR = 0.78, 95%CI: 0.63-0.96) had a lower colorectal cancer risk.
[CONCLUSION] We observed some associations between occupational EDC exposure and colorectal cancer risk. Further investigation of these relationships is warranted.