Editorial: Novel techniques for colorectal cancer.

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide. Despite significant advancements in systemic therapies, the management of locally advanced and metastatic disease, including peritoneal and liver metastases, continues to present complex clinical challenges. The evolution of treatment paradigms from purely systemic approaches to aggressive, multimodal strategies underscores the necessity for continuous innovation in surgical techniques, targeted therapies, and diagnostic tools. In this research topic, we present a collection of four insightful articles that address critical aspects of CRC management. These contributions span the spectrum of care, from refining surgical safety and exploring novel combination therapies to leveraging machine learning for early detection, thereby reflecting the multidisciplinary nature of modern oncologic care.