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UBR4 enhances efficacy of anti-EGFR antibody by facilitating clathrin-dependent EGFR endocytosis in colorectal cancer.

2/5 보강

Journal of gastroenterology 📖 저널 OA 33.3% 2024~2026 2026 Vol.61(4) p. 421-434 HER2/EGFR in Cancer Research

TL;DR UBR4 promotes clathrin-dependent EGFR degradation, enhancing anti-EGFR therapeutic efficacy, and may serve as a predictive biomarker in metastatic CRC.

PICO 자동 추출 (휴리스틱, conf 2/4)

유사 논문

P · Population 대상 환자/모집단

추출되지 않음

I · Intervention 중재 / 시술

cetuximab and EGFR internalization was analyzed using siRNA knockdowns, inhibitors, and proteomic analyses

C · Comparison 대조 / 비교

추출되지 않음

O · Outcome 결과 / 결론

High UBR4 expression in CRC tissues correlated with better responses and longer progression-free survival in patients treated with anti-EGFR mAb therapy. [CONCLUSIONS] UBR4 promotes clathrin-dependent EGFR degradation, enhancing anti-EGFR therapeutic efficacy, and may serve as a predictive biomarker in metastatic CRC.

OpenAlex 토픽 · HER2/EGFR in Cancer Research Colorectal Cancer Treatments and Studies Wnt/β-catenin signaling in development and cancer

Fukuya A, Sato Y, Okada Y, Sagawa T, Kawano Y, Bando M

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

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