Precision conversion of colorectal cancer lung metastases: A personalized quadruplet regimen integrating photodynamic therapy with targeted, immunotherapy, and chemotherapy.
[SIGNIFICANCE] Colorectal cancer (CRC) has a high incidence and mortality rate, with lung metastasis being the second most common site.
APA
Han Q, Gao L, et al. (2026). Precision conversion of colorectal cancer lung metastases: A personalized quadruplet regimen integrating photodynamic therapy with targeted, immunotherapy, and chemotherapy.. Photodiagnosis and photodynamic therapy, 58, 105362. https://doi.org/10.1016/j.pdpdt.2026.105362
MLA
Han Q, et al.. "Precision conversion of colorectal cancer lung metastases: A personalized quadruplet regimen integrating photodynamic therapy with targeted, immunotherapy, and chemotherapy.." Photodiagnosis and photodynamic therapy, vol. 58, 2026, pp. 105362.
PMID
41580231
Abstract
[SIGNIFICANCE] Colorectal cancer (CRC) has a high incidence and mortality rate, with lung metastasis being the second most common site. Current treatments have limited efficacy, and novel approaches are needed.
[APPROACH] We report a case of a middle-aged female with CRC and lung metastasis treated with four cycles of PDT and five cycles of systemic therapy, including chemotherapy, targeted therapy, and immunotherapy.
[RESULTS] After treatment, the lung metastases showed cystic changes, and the primary tumor significantly regressed (TRG: AJCC 0, Becker 1a). The patient successfully underwent surgical treatment.
[CONCLUSIONS] This multimodal therapy shows promise in CRC lung metastasis, offering new insights for treatment.
[APPROACH] We report a case of a middle-aged female with CRC and lung metastasis treated with four cycles of PDT and five cycles of systemic therapy, including chemotherapy, targeted therapy, and immunotherapy.
[RESULTS] After treatment, the lung metastases showed cystic changes, and the primary tumor significantly regressed (TRG: AJCC 0, Becker 1a). The patient successfully underwent surgical treatment.
[CONCLUSIONS] This multimodal therapy shows promise in CRC lung metastasis, offering new insights for treatment.
MeSH Terms
Humans; Lung Neoplasms; Female; Photochemotherapy; Colorectal Neoplasms; Middle Aged; Immunotherapy; Photosensitizing Agents; Combined Modality Therapy; Precision Medicine; Antineoplastic Combined Chemotherapy Protocols
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