Young adults undergoing anterior resection for colorectal cancer experience fewer medical complications but a comparable risk of anastomotic leak.
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TL;DR
It is hypothesized that younger adults have lower rates of anastomotic leak after anterior resection than that of older adults.
OpenAlex 토픽 ·
Colorectal Cancer Surgical Treatments
Cardiac, Anesthesia and Surgical Outcomes
Colorectal Cancer Treatments and Studies
It is hypothesized that younger adults have lower rates of anastomotic leak after anterior resection than that of older adults.
- p-value p < 0.001
- OR 1.05
APA
Sarah E. Rudasill, Rebecca B. Tang, et al. (2026). Young adults undergoing anterior resection for colorectal cancer experience fewer medical complications but a comparable risk of anastomotic leak.. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 28(4), e70425. https://doi.org/10.1111/codi.70425
MLA
Sarah E. Rudasill, et al.. "Young adults undergoing anterior resection for colorectal cancer experience fewer medical complications but a comparable risk of anastomotic leak.." Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, vol. 28, no. 4, 2026, pp. e70425.
PMID
41872122 ↗
Abstract 한글 요약
[AIM] The incidence of colorectal cancer in adults <50 years old is rising, yet data to guide preoperative counselling of younger patients are limited. We hypothesized that younger adults have lower rates of anastomotic leak after anterior resection than that of older adults.
[METHODS] Adults undergoing elective anterior resection for nonmetastatic colorectal cancer were identified from the American College of Surgeons National Surgical Quality Improvement Program (2012-2023) and stratified by age (<50 vs ≥50 years). Multivariable analyses evaluated associations between age and postoperative outcomes, including anastomotic leak, reoperation, and respiratory and renal complications.
[RESULTS] Of 42,633 patients, 7213 (16.9%) were <50 years. Younger patients had lower rates of diabetes (7.0 vs. 19.3%, p < 0.001) but were more often obese (17.7 vs. 14.5%, p < 0.001) and diagnosed with rectal cancer (46.2 vs. 39.8%, p < 0.001). On univariate analysis, younger patients had similar leak rates compared with older patients (3.4 vs. 3.5%, p = 0.70) but fewer respiratory (0.7 vs. 2.2%, p < 0.001) and renal (0.9 vs. 2.3%, p < 0.001) complications. On multivariable analysis, younger age was not associated with risk of leak (OR = 1.05, p = 0.54) or reoperation (OR = 0.92, p = 0.21) but was protective against respiratory (OR = 0.40, p < 0.001) and renal (OR = 0.48, p < 0.001) complications. Protective factors against leak included faecal diversion (OR = 0.87, p = 0.03), female sex (OR = 0.61, p < 0.001), laparoscopic approach (OR = 0.75, p < 0.001), preoperative antibiotics (OR = 0.63, p < 0.001) and nonsmoking status (OR = 0.69, p < 0.001).
[CONCLUSION] Younger colorectal cancer patients had fewer comorbidities and medical complications but similar anastomotic leak and reoperation rates compared to older adults, highlighting the importance of preoperative counselling to guide patient expectations.
[METHODS] Adults undergoing elective anterior resection for nonmetastatic colorectal cancer were identified from the American College of Surgeons National Surgical Quality Improvement Program (2012-2023) and stratified by age (<50 vs ≥50 years). Multivariable analyses evaluated associations between age and postoperative outcomes, including anastomotic leak, reoperation, and respiratory and renal complications.
[RESULTS] Of 42,633 patients, 7213 (16.9%) were <50 years. Younger patients had lower rates of diabetes (7.0 vs. 19.3%, p < 0.001) but were more often obese (17.7 vs. 14.5%, p < 0.001) and diagnosed with rectal cancer (46.2 vs. 39.8%, p < 0.001). On univariate analysis, younger patients had similar leak rates compared with older patients (3.4 vs. 3.5%, p = 0.70) but fewer respiratory (0.7 vs. 2.2%, p < 0.001) and renal (0.9 vs. 2.3%, p < 0.001) complications. On multivariable analysis, younger age was not associated with risk of leak (OR = 1.05, p = 0.54) or reoperation (OR = 0.92, p = 0.21) but was protective against respiratory (OR = 0.40, p < 0.001) and renal (OR = 0.48, p < 0.001) complications. Protective factors against leak included faecal diversion (OR = 0.87, p = 0.03), female sex (OR = 0.61, p < 0.001), laparoscopic approach (OR = 0.75, p < 0.001), preoperative antibiotics (OR = 0.63, p < 0.001) and nonsmoking status (OR = 0.69, p < 0.001).
[CONCLUSION] Younger colorectal cancer patients had fewer comorbidities and medical complications but similar anastomotic leak and reoperation rates compared to older adults, highlighting the importance of preoperative counselling to guide patient expectations.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Female
- Male
- Middle Aged
- Anastomotic Leak
- Age Factors
- Adult
- Colorectal Neoplasms
- Risk Factors
- Aged
- Postoperative Complications
- Reoperation
- Retrospective Studies
- Proctectomy
- Elective Surgical Procedures
- Incidence
- anastomotic leak
- colorectal cancer
- early‐onset colorectal cancer
- low anterior resection
- postoperative complications
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