Isoeugenol Inhibits Growth, Migration, and Invasion in Colorectal Cancer Cells With Distinct Molecular Characteristics.
2/5 보강
OpenAlex 토픽 ·
Piperaceae Chemical and Biological Studies
Oral Health Pathology and Treatment
Ginger and Zingiberaceae research
Colorectal cancer (CRC) is the second common cause of cancer death in the world and its development can be regulated by herbal compounds.
APA
Zih‐Shuan Liou, Chih‐Chun Kuo, et al. (2026). Isoeugenol Inhibits Growth, Migration, and Invasion in Colorectal Cancer Cells With Distinct Molecular Characteristics.. Molecular nutrition & food research, 70(8), e70466. https://doi.org/10.1002/mnfr.70466
MLA
Zih‐Shuan Liou, et al.. "Isoeugenol Inhibits Growth, Migration, and Invasion in Colorectal Cancer Cells With Distinct Molecular Characteristics.." Molecular nutrition & food research, vol. 70, no. 8, 2026, pp. e70466.
PMID
41988864 ↗
Abstract 한글 요약
Colorectal cancer (CRC) is the second common cause of cancer death in the world and its development can be regulated by herbal compounds. Unfortunately, little information is known about the signal pathways of Piper betle isoeugenol in CRC cells (CRCCs). Using three CRC cell lines (SW480, SW620, and HCT116) that represent different molecular characteristics and serve as in vitro models of CRC progression, we found that isoeugenol inhibited cell growth. Wound healing and Boyden chamber assays indicated that isoeugenol inhibited the migration and invasion in CRCCs. Mechanistically, isoeugenol suppressed key regulators of cell cycle progression and epithelial-mesenchymal transition (EMT), including pAKT, CDK4, CDK6, cyclin D1, N-cadherin, and Snail, while increasing the levels of pAMPK, pJNK, pp38 MAPK, and E-cadherin. Cell line-specific modulation of CDK2, cyclin D3, p21, p27, and pERK proteins was also observed. Furthermore, isoeugenol inhibited the enzymatic activities of MMP-2 and MMP-9. Pharmacological inhibition of AMPK or p38 antagonized isoeugenol-suppressed cell growth, migration, invasion, and associated signaling events. In conclusion, these data suggest that isoeugenol may inhibit CRCC growth, migration, and invasion through activations of AMPK and p38 MAPK pathways and modulating pathways involved in cell cycle regulation and EMT.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Cell Movement
- Colorectal Neoplasms
- Eugenol
- Cell Line
- Tumor
- Epithelial-Mesenchymal Transition
- Cell Proliferation
- Neoplasm Invasiveness
- Cadherins
- Matrix Metalloproteinase 9
- Matrix Metalloproteinase 2
- HCT116 Cells
- AMP-Activated Protein Kinases
- Cell Cycle
- colorectal cancer cells
- growth
- invasion
- isoeugenol
- migration
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Comprehensive analysis of androgen receptor splice variant target gene expression in prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.