Bioactive fructans from Bacillus subtilis and the multifunctional role of L3 with cytotoxic, anticoagulant, and antimicrobial activities.
2/5 보강
OpenAlex 토픽 ·
Microbial Metabolites in Food Biotechnology
Diet, Metabolism, and Disease
Seaweed-derived Bioactive Compounds
This study examined how culture conditions affect the molecular weight (MW), structure, and function of four Bacillus subtilis fructans (L1-L4).
APA
Amira A. Gamal, Asmaa Ezzat, et al. (2026). Bioactive fructans from Bacillus subtilis and the multifunctional role of L3 with cytotoxic, anticoagulant, and antimicrobial activities.. Food chemistry, 516, 149339. https://doi.org/10.1016/j.foodchem.2026.149339
MLA
Amira A. Gamal, et al.. "Bioactive fructans from Bacillus subtilis and the multifunctional role of L3 with cytotoxic, anticoagulant, and antimicrobial activities.." Food chemistry, vol. 516, 2026, pp. 149339.
PMID
42035641 ↗
Abstract 한글 요약
This study examined how culture conditions affect the molecular weight (MW), structure, and function of four Bacillus subtilis fructans (L1-L4). The polysaccharides (170-34 kDa) were characterized using TLC, FTIR, and NMR, revealing clear MW-dependent bioactivities. The highest-MW fructan, L1 (170 kDa), showed broad antimicrobial effects and strong prebiotic activity with minimal cytotoxicity. L2 (61 kDa) demonstrated exceptional anticoagulant efficacy, extending clotting time to 187 min, surpassing heparin. The low-MW L3 (34 kDa), enriched in extended β-(2 → 6) linkages, exhibited the strongest anticancer effect against HCT-116 cells (IC₅₀ = 44.7 μg), inducing apoptosis via P53 and Bax upregulation and Bcl-2 suppression. L3 also retained antimicrobial and antioxidant activity (21% DPPH scavenging) alongside prebiotic benefits. All fructans exceeded Hemoclar in fibrinolytic potential. Overall, the results establish a clear MW-function relationship and highlight L3 as a promising multifunctional candidate for biomedical use.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- Systemic Inflammation and Survival in Stage IV Colorectal Cancer: A Retrospective Cohort Study.
- A subset of MMR-proficient colon cancers responds to neoadjuvant immunotherapy.
- Prognostic Value of the Cancer Inflammation Prognostic Index (CIPI) in De Novo Metastatic Colon Cancer: A Multicenter Retrospective Cohort Study.
- Liver Abscess as the Herald of Underlying Colorectal Neoplasm.
- CircNOLC1/KRT16 promotes colorectal cancer invasion and migration via c-met nuclear translocation and reprogramming of the oxidative pentose phosphate pathway.
- Compliance and Quality of Endoscopic Tattooing in Colorectal Cancer: A Retrospective Audit.