Development of Preclinical Mouse Hepatic Artery Embolization Model for Translational Research in IR.
2/5 보강
TL;DR
A mouse hepatic artery embolization (HAE) model for translational research of interventional oncology might provide a valuable platform for translational research of interventional oncology.
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
microbead injections (HAE group), and 5 served as controls
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Histological analysis revealed larger necrotic areas in the HAE group than in controls (interquartile range, 6.0%-34.9% vs 0.0%-0.5%; P < .05). This model might provide a valuable platform for translational research of interventional oncology.
OpenAlex 토픽 ·
Hepatocellular Carcinoma Treatment and Prognosis
Liver physiology and pathology
Angiogenesis and VEGF in Cancer
A mouse hepatic artery embolization (HAE) model for translational research of interventional oncology might provide a valuable platform for translational research of interventional oncology.
- p-value P < .001
- p-value P < .05
APA
Reona Wada, Haruyuki Takaki, et al. (2026). Development of Preclinical Mouse Hepatic Artery Embolization Model for Translational Research in IR.. Journal of vascular and interventional radiology : JVIR, 37(5), 108574. https://doi.org/10.1016/j.jvir.2026.108574
MLA
Reona Wada, et al.. "Development of Preclinical Mouse Hepatic Artery Embolization Model for Translational Research in IR.." Journal of vascular and interventional radiology : JVIR, vol. 37, no. 5, 2026, pp. 108574.
PMID
41643993 ↗
Abstract 한글 요약
This proof-of-concept study with short-term follow-up reports the development of a mouse hepatic artery embolization (HAE) model for translational research of interventional oncology. To induce liver metastases, luciferase-expressing colon cancer cells were injected into the spleens of BALB/c mice. After confirming hepatic tumor engraftment, HAE was performed by retrograde puncture of the lienogastric artery using a 34-gauge needle under microscopy. Six mice received microbead injections (HAE group), and 5 served as controls. Technical success rate was 100%; however, 2-day survival was 67% (4 of 6) for the HAE group. Bioluminescent imaging the day after the procedure showed a significant reduction in luciferase activity for the HAE group (P < .001), but not for controls (P = .367). Histological analysis revealed larger necrotic areas in the HAE group than in controls (interquartile range, 6.0%-34.9% vs 0.0%-0.5%; P < .05). This model might provide a valuable platform for translational research of interventional oncology.
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