Hydroxypropyl‑β‑cyclodextrin/thymoquinone inclusion complex inhibits non‑small cell lung cancer progression through NF‑κB‑mediated ferroptosis.
1/5 보강
Thymoquinone (TQ) is a quinone isolated from the black seed and has been extensively investigated in the pharmaceutical field due to its promising therapeutic value.
APA
Zheng WW, Ding JX, et al. (2025). Hydroxypropyl‑β‑cyclodextrin/thymoquinone inclusion complex inhibits non‑small cell lung cancer progression through NF‑κB‑mediated ferroptosis.. Oncology reports, 54(6). https://doi.org/10.3892/or.2025.8990
MLA
Zheng WW, et al.. "Hydroxypropyl‑β‑cyclodextrin/thymoquinone inclusion complex inhibits non‑small cell lung cancer progression through NF‑κB‑mediated ferroptosis.." Oncology reports, vol. 54, no. 6, 2025.
PMID
40970359 ↗
Abstract 한글 요약
Thymoquinone (TQ) is a quinone isolated from the black seed and has been extensively investigated in the pharmaceutical field due to its promising therapeutic value. There have been reports on the potential anti‑cancer properties of TQ, whereas the clinical application of TQ is greatly restricted by its low water solubility and poor delivery. In the present study, TQ was encapsulated into hydroxypropyl‑β‑cyclodextrin (HP‑β‑CD) using the freeze‑drying method to form a TQ/HP‑β‑CD inclusion complex. Then, the TQ/HP‑β‑CD inclusion complex was characterized by Fourier transform infrared, differential scanning calorimetry, X‑ray diffraction and scanning electron microscopy. HP‑β‑CD as an excipient significantly enhances the water solubility of TQ, and TQ/HP‑β‑CD demonstrated excellent biocompatibility on normal cells both and . Moreover, the complexation with HP‑β‑CD enhanced the anticancer activity of TQ against non‑small cell lung cancer cells and its mechanism of action is related to ferroptosis mediated by NF‑κB. Such an enhanced cytotoxic effect may be attributed to the effective complexation of TQ in HP‑β‑CD, which enhances its water solubility and bioavailability.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- 2-Hydroxypropyl-beta-cyclodextrin
- Carcinoma
- Non-Small-Cell Lung
- NF-kappa B
- Ferroptosis
- Benzoquinones
- Lung Neoplasms
- Animals
- Mice
- Cell Line
- Tumor
- Xenograft Model Antitumor Assays
- Solubility
- Cell Proliferation
- A549 Cells
- Disease Progression
- ferroptosis
- hydroxypropyl‑β‑cyclodextrin
- inclusion complex
- non‑small cell lung cancer
- thymoquinone
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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