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Paraneoplastic Raynaud's Phenomenon: A Case Report.

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Cureus 📖 저널 OA 99.9% 2021: 42/43 OA 2022: 79/79 OA 2023: 181/181 OA 2024: 284/284 OA 2025: 774/774 OA 2026: 506/506 OA 2021~2026 2025 Vol.17(12) p. e99075
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Vitó Madureira B, Aranha R, Soares Costa R

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Raynaud's phenomenon is a vasospastic disorder that may occur as a primary benign condition or as a secondary manifestation of systemic disease.

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APA Vitó Madureira B, Aranha R, Soares Costa R (2025). Paraneoplastic Raynaud's Phenomenon: A Case Report.. Cureus, 17(12), e99075. https://doi.org/10.7759/cureus.99075
MLA Vitó Madureira B, et al.. "Paraneoplastic Raynaud's Phenomenon: A Case Report.." Cureus, vol. 17, no. 12, 2025, pp. e99075.
PMID 41531633 ↗

Abstract

Raynaud's phenomenon is a vasospastic disorder that may occur as a primary benign condition or as a secondary manifestation of systemic disease. We describe the case of a 63-year-old man, with stage IV squamous cell carcinoma of the left lung undergoing palliative chemotherapy, who developed asymmetric and transient discoloration of the distal upper extremities. The patient's clinical history of active cancer, combined with exclusion of other secondary causes, supported a paraneoplastic etiology. Paraneoplastic Raynaud's phenomenon should be considered in adults with atypical or new-onset vasospastic symptoms, especially in the context of established malignancy. Early recognition is essential to optimize symptom management and enhance understanding of paraneoplastic vascular syndromes associated with lung cancer.

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