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3건 · 최신순-
Resolving the Molecular Steps in Clostridial Neurotoxin Light Chain Translocation.
The clostridial neurotoxins (CNTs), botulinum toxin and tetanus toxin, are the most toxic proteins for humans. Neurotoxicity is based upon the specificity of the CNTs for neural host receptors and substrates. CNTs are organized into three d…
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Entry of Botulinum Neurotoxin Subtypes A1 and A2 into Neurons.
Botulinum neurotoxins (BoNTs) are the most toxic proteins for humans but also are common therapies for neurological diseases. BoNTs are dichain toxins, comprising an N-terminal catalytic domain (LC) disulfide bond linked to a C-terminal hea…
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Protein Structure Facilitates High-Resolution Immunological Mapping.
Select agents (SA) pose unique challenges for licensing vaccines and therapies. In the case of toxin-mediated diseases, HHS assigns guidelines for SA use, oversees vaccine and therapy development, and approves animal models and approaches t…