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Venetoclax and ibrutinib: Two partners for the front-line treatment of chronic lymphocytic leukemia.
The combination of ibrutinib and venetoclax (I+V), has shown benefit in treating chronic lymphocytic leukemia (CLL) due to their complementary mechanisms of action and synergistic effects. The fixed duration of the I+V regimen results in hi…
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Clinical and transcriptomic characterization of patients with chronic lymphocytic leukemia harboring t(14;19): an ERIC study.
In chronic lymphocytic leukemia (CLL), the role of complex karyotype (CK) for prognostic stratification remains a topic of debate, and the impact of specific cytogenetic abnormalities is still unclear. This study aims to investigate the cli…
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Lights and shades of front-line treatment with covalent BTK inhibitors combined with venetoclax in patients with chronic lymphocytic leukemia.
This review focused on trials investigating the front-line covalent BTK inhibitors (cBTKi) and venetoclax (V) combination administered in a fixed-duration (CAPTIVATE, GLOW, AMPLIFY trials) or minimal residual disease (MRD)-guided manner (MD…