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Large well-differentiated hepatocellular carcinoma in patients with HBV: gadoxetic acid-enhanced MR imaging features and prognosis.
[OBJECTIVE] To explore the gadoxetic acid-enhanced MR imaging features and prognosis of large well-differentiated hepatocellular carcinoma (LWDHCC) (≥ 3 cm) in patients with HBV. [MATERIALS AND METHODS] One hundred and eighty-two patients …
- Retraction: LncRNA CHRFinduced miR-489 loss promotes metastasis of colorectal cancer via TWIST1/EMT signaling pathway.
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Anti-tumor effect of flavonoids isolated from Bidens Pilosa L. by regulating the activity of myeloid-derived suppressor cells within the tumor microenvironment in mice.
[ETHNOPHARMACOLOGICAL RELEVANCE] Colon cancer is one of the most common malignant tumors worldwide. Bidens pilosa L., an annual herb of the Asteraceae, has long been used to treat inflammatory-related illnesses, including cancer. As a popul…
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Design, Synthesis, Bioactivity, and Docking Studies of Isatin-Hydrazone Derivatives as Potential CDK-2 Inhibitors.
[INTRODUCTION] Isatin derivatives are an important class of nitrogen-containing heterocyclic compounds that have exhibited a broad spectrum of pharmacological and biological activities. The condensation reaction of isatin readily forms C=N-…
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Integrated multi-omics identifies MCRS1 as a causal hub linking aging, metabolic syndrome, and breast cancer progression.
[PURPOSE] Aging and metabolic syndrome (MetS) are intertwined risk factors for breast cancer (BC), but the core molecular nexus integrating these states is unknown. This study aimed to identify and validate a causal driver at this intersect…
- Comment on "Exercise-induced extracellular vesicles delay tumor development by igniting inflammation in an immunologically cold triple-negative breast cancer mouse model".
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Uncovering the symptom relationship among sleep quality, anxiety, and depression in Chinese patients with breast cancer: multidimensional data validation using PSQI versus actigraphy.
[PURPOSE] The interplay between sleep quality, anxiety, and depression among breast cancer patients remains poorly understood. This study aimed to investigate and compare the symptoms relationships among these three factors in Chinese breas…
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Development and validation of a nomogram for false-negative results in fine-needle aspiration of axillary lymph nodes in breast cancer.
[OBJECTIVE] To construct and validate a nomogram for predicting false-negative results of axillary lymph node (ALN) fine needle aspiration (FNA) in breast cancer (BC). [METHODS] Using the surgical pathological results of axillary lymph nod…
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S100A4: A calcium-binding protein at the crossroads of cancer, fibrosis, and antiviral immunity.
S100A4 is a calcium-binding protein and plays critical roles in cellular migration, cytoskeletal dynamics by directly interacting with the actomyosin cytoskeleton and functioning extracellularly as a damage-associated molecular pattern (DAM…
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Integrating transcriptomic profiling and machine learning: A clinically actionable prognostic model for infant acute myeloid leukemia.
Infant acute myeloid leukemia (AML), particularly in those under 3 years of age, presents poor prognostic outcomes and distinct biological characteristics that require age-specific risk assessment. This study, utilizing data from four pedia…
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Exploring the potential toxic mechanisms of bisphenol F exposure in acute myeloid leukemia: Insights from network toxicology, molecular docking and experimental validation.
Bisphenol F (BPF), a major alternative to bisphenol A (BPA), is now widely used worldwide, posing significant risks to human health and the environment. Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy with a poor …
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Arsenic Sulfide Induces Apoptosis in Myelodysplastic Neoplasm Cells Through the Suppression of ABI2.
[BACKGROUND] Myelodysplastic neoplasms (MDS) are a category of myeloid malignancies that can progress to acute myeloid leukemia (AML). Arsenic sulfide (As₂S₂) has demonstrated efficacy in the treatment of MDS. However, further investigation…
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Stent Patency and Survival after PTBD and Biliary Stenting for Pancreatic Cancer: A 5-Year Retrospective Cohort Study.
[BACKGROUND] Obstructive jaundice commonly complicates pancreatic cancer and often requires biliary decompression. Percutaneous transhepatic biliary drainage (PTBD) followed by stent placement is used for palliation, but long-term stent pat…
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Systematic Pan-Cancer Analysis Identifies PHF6 as an Immunological and Prognostic Biomarker.
: PHF6 is a chromatin-binding protein located in the nucleus, and it is involved in transcriptional regulation. However, limited research exists on the specific roles and mechanisms of PHF6 across various tumors. : Based on The Cancer Genom…
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Nomogram Prediction Model of Thyroid Nodule in Healthcare Professionals: Based on Physical and Psychological Risk Factors.
[BACKGROUND] Thyroid nodules are a common condition with a 7-15% likelihood of developing thyroid cancer. The prevalence of thyroid nodules in healthcare professionals is poorly understood, and how psychosomatic factors affect the occurrenc…
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Health utility scores of six common cancers in China measured by SF-6Dv2.
[PURPOSE] Given the recent update of SF-6Dv2, detailed data on utility scores for cancer patients by cancer type remain scarce in China and other regions, which limits the precision of cost-utility analyses (CUA) in cancer interventions. Th…
- Retraction: MicroRNA-216a inhibits the metastasis of gastric cancer cells by targeting JAK2/STAT3-mediated EMT process.
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The Role of MAPK12 in Prognosis of Patients With Liver Cancer and Effects on Stemness Characteristics.
Liver hepatocellular carcinoma (LIHC) is a prevalent and highly aggressive form of liver cancer, characterized by increasing rates of incidence and mortality globally. Although numerous treatment options currently exist, they frequently res…
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SCRN1 confers hepatocellular carcinoma resistance to ferroptosis by stabilizing GPX4 via STK38-mediated phosphorylation.
Systemic therapy is the optimal choice for individuals with unresectable or advanced hepatocellular carcinoma (HCC). However its effectiveness is constrained by resistance. Ferroptosis is a unique form of regulated cell death and plays an e…
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To Post or not to Post? That is the Question. Relationship between Selfie Behavior and Cosmetic Surgery Attitude among Chinese Young Adult Women: Mediation of Negative Physical Self.
[BACKGROUND] Recently, young women have become the primary drivers of the increasing demand for cosmetic surgery. Previous studies have indicated a significant positive correlation between selfies and considering cosmetic surgery. However, …
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MicroRNA-486-3p Targets Chymotrypsin C to Regulate Pancreatic Cancer Progression and Immunosuppressive Factor Expression.
Pancreatic ductal adenocarcinoma (PDAC) is a common digestive system tumor with high mortality rates and a poor prognosis. Reports suggest that microRNA (miR)-486-3p in PDAC can be used as a diagnostic biomarker. This research aimed to eluc…
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New Insights into Immune Cells and Immunotherapy for Thyroid Cancer.
Thyroid cancer (TC) is the most common endocrine malignancy worldwide, and the incidence of TC has gradually increased in recent decades. Differentiated thyroid cancer (DTC) is the most common subtype and has a good prognosis. However, adva…