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Development and characterisation of a 3D multi-cellular in vitro model of normal human breast: a tool for cancer initiation studies.
Multicellular 3-dimensional (3D) in vitro models of normal human breast tissue to study cancer initiation are required. We present a model incorporating three of the major functional cell types of breast, detail the phenotype and document o…
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Distinct expression patterns of ER alpha and ER beta in normal human mammary gland.
[AIM] Two oestrogen receptors (ERs) have been identified to date-the "classic" ER alpha and the more recently described ER beta. Although much is known about ER alpha at the mRNA and protein levels, our knowledge of the expression and distr…
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Expression of alternatively spliced estrogen receptor alpha mRNAs is increased in breast cancer tissues.
We previously identified 20 different alternatively spliced estrogen receptor alpha (ERalpha) mRNAs that have deletions in various combinations of exons in breast cancer cell lines using a novel 'Splice Targeted Approach' [J. Steroid Bioche…
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Identification of wild-type and exon 5 deletion variants of estrogen receptor beta in normal human mammary gland.
We have examined messenger RNA (mRNA) expression of estrogen receptor (ER) alpha, wild-type ERbeta (mRNA and protein), and ERbeta exon 5 deletion variants (ERbeta delta5) in samples of normal human mammary gland obtained from 37 premenopaus…
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Interleukin-3: a putative protective factor against breast cancer which is secreted by male but not female breast fibroblasts.
The enzyme 17 beta-hydroxysteroid dehydrogenase (17-HSD) is a key regulator of intracellular 17 beta-estradiol (E2), which is associated with breast cancer and is influenced by paracrine factors released by breast-cancer fibroblasts. Since …