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Gleason Grade Group 3 Represents a Spectrum of Disease: Results from a Large Institutional Cohort.
[BACKGROUND AND OBJECTIVE] A biopsy diagnosis of Gleason grade group (GG) 3 prostate cancer (PC) automatically classifies patients as having at least unfavorable intermediate-risk disease warranting definitive treatment. We hypothesized tha…
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A High Decipher Genomic Risk Score Is Associated with Major Pathological Progression in Patients Undergoing Active Surveillance for Prostate Cancer.
Genomic testing has potential to improve clinical decision-making for men with prostate cancer, but is understudied for active surveillance (AS), the standard management option for favorable-risk disease. We investigated whether Decipher sc…
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Molecular Biomarkers for Localized Prostate Cancer: Current Progress and Future Directions.
This article examines the current landscape of molecular biomarkers for diagnosing localized prostate cancer (PCa), from the prostate-specific antigen (PSA) test to newer blood, urine, or tissue-based biomarkers which can improve the accura…
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The Natural History of Confirmed Grade Group 1 Prostate Cancer Managed with Active Surveillance in the Modern Era.
[BACKGROUND AND OBJECTIVE] Grade group 1 (GG1, Gleason 3 + 3) prostate cancer (PCa) is considered low risk but can upgrade, and is managed with active surveillance (AS). Amidst recent controversy of whether GG1 PCa should be called cancer, …
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Determining Optimal Patient Selection for High-intensity Focused Ultrasound for Prostate Cancer.
[BACKGROUND AND OBJECTIVE] Magnetic resonance imaging (MRI)/ultrasound-guided high-intensity focused ultrasound (HIFU) ablates prostate cancer with promising cancer control and minimal impact on sexual or urinary function. However, recurren…