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Rac1 palmitoylation is required for cardiac stress adaptation and regulation of protein kinase A signaling.
Cardiac hypertrophy is a common adaptation to cardiovascular stress and often a prelude to heart failure. We examined how S-palmitoylation of the small GTPase, Ras-related C3 botulinum toxin substrate 1 (Rac1), impacts cardiomyocyte stress …
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Cardiomyocyte Rac1 signaling in hypertrophy, arrhythmia, and cardiac stress adaptation.
Cardiovascular disease remains the leading cause of mortality globally and is often marked by pathologic cardiac remodeling including hypertrophy and fibrosis that promote the progression to heart failure. Ras-related C3 botulinum toxin sub…