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The influence of obesity on folate status, DNA methylation and cancer-related gene expression in normal breast tissues from premenopausal women.
Epidemiological studies have established obesity as a critical risk factor for postmenopausal breast cancer (post-BC), whereas a reverse association holds prior to menopause. A significant scientific gap exists in understanding the mechanis…
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Inter-Individual Variation in Response to Estrogen in Human Breast Explants.
Exposure to estrogen is strongly associated with increased breast cancer risk. While all women are exposed to estrogen, only 12% are expected to develop breast cancer during their lifetime. These women may be more sensitive to estrogen, as …
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Investigation of the adolescent female breast transcriptome and the impact of obesity.
[BACKGROUND] Early life environmental exposures affect breast development and breast cancer risk in adulthood. The breast is particularly vulnerable during puberty when mammary epithelial cells proliferate exponentially. In overweight/obese…
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The influence of tumor necrosis factor-α on the tumorigenic Wnt-signaling pathway in human mammary tissue from obese women.
Epidemiological studies have convincingly suggested that obesity is an important risk factor for postmenopausal breast cancer, but the mechanisms responsible for this relationship are still not fully understood. We hypothesize that obesity …
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DNA methylation in paired breast epithelial and white blood cells from women undergoing reduction mammoplasty.
[BACKGROUND] The extent to which white blood cell (WBC) DNA methylation provides information on the status of breast epithelial cell DNA is unknown. [PATIENTS AND METHODS] We examined the correlation between methylation in Ras-association …
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Parity-related molecular signatures and breast cancer subtypes by estrogen receptor status.
[INTRODUCTION] Relationships of parity with breast cancer risk are complex. Parity is associated with decreased risk of postmenopausal hormone receptor-positive breast tumors, but may increase risk for basal-like breast cancers and early-on…
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SKP2 overexpression is associated with increased serine 10 phosphorylation of p27 (pSer10p27) in triple-negative breast cancer.
S-phase kinase-associated protein 2 (SKP2) is an important cell cycle regulator, targeting the cyclin-dependent kinase (CDK) inhibitor p27 for degradation, and is frequently overexpressed in breast cancer. p27 regulates G1 /S transition by …
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Activation of host wound responses in breast cancer microenvironment.
[PURPOSE] Cancer progression is mediated by processes that are also important in wound repair. As a result, cancers have been conceptualized as overhealing wounds or "wounds that do not heal," and gene expression signatures reflective of wo…