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Mantle cell lymphoma exhibiting repeated progression with the initiation of a JAK-1 inhibitor for psoriatic arthritis.
Mantle cell lymphoma (MCL) associated with immunodeficiency or dysregulation (IDD) has not been linked to the use of JAK inhibitors (JAKi). While the development of lymphoma in patients receiving JAKi for rheumatoid arthritis and psoriatic …
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Impact of Peri-Procedural Antibiotics on Post-ERCP Infectious Adverse Events With Distal Malignant Biliary Obstruction.
[BACKGROUND AND AIMS] Malignant biliary obstruction (MBO) often necessitates endoscopic retrograde cholangiopancreatography (ERCP) for biliary drainage. Although ERCP is the standard treatment, post-procedural infections such as cholangitis…
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Clinical and imaging differences between pancreatic carcinoma in situ and T1a/T1b pancreatic ductal adenocarcinoma.
[BACKGROUND/OBJECTIVES] Accurate differentiation between pancreatic carcinoma in situ (CIS) and small invasive pancreatic ductal adenocarcinoma (PDAC) is critical for optimizing patient management. This study aimed to assess the diagnostic …
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Identifying risk factors for pancreatic cancer in a large Japanese cohort using an insurance and health check-up database.
[BACKGROUND] Pancreatic cancer (PC) has a poor prognosis, with most cases diagnosed at an unresectable stage. Identifying high-risk individuals within the general population is essential for targeted surveillance and early detection. We aim…
- Beyond Helicobacter pylori Eradication: Endoscopic Surveillance of the Post-Eradication Stomach.
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Repeated pancreatic juice cytology via endoscopic nasopancreatic drainage catheter combined with clinical findings improves diagnostic ability for malignant cases of suspected pancreatic cancer with non-identifiable tumors.
[BACKGROUND/OBJECTIVES] The detection of pancreatic cancer (PC) often depends on indirect indicators such as parenchyma atrophy (PPA), main pancreatic duct stenosis, and low echoic areas, particularly when no mass is evident on imaging. Whi…
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Minor papilla approach improves technical success of nasopancreatic drainage-based pancreatic juice cytology for early pancreatic cancer diagnosis.
[BACKGROUND AND STUDY AIMS] Early detection of pancreatic cancer (PC) is vital for improving survival, yet it often relies on indirect imaging findings rather than detection of distinct masses. Recently, pancreatic juice cytology obtained v…
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Phase 2 study of futibatinib in patients with gastric or gastroesophageal junction cancer harboring FGFR2 amplifications.
[BACKGROUND AND AIMS] Aberrant fibroblast growth factor receptor (FGFR)-driven signaling, predominantly arising from FGFR2 amplification, plays a key role in gastric cancer pathogenesis. This open-label, phase 2 study evaluated the efficacy…
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Pancreatic cancer risk in diabetic patients using the Japanese Regional Insurance Claims.
Pancreatic cancer presents a critical health issue characterized by low survival rates. Identifying risk factors in specific populations, such as those with diabetes, is crucial for early detection and improved outcomes. This study aimed to…