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Prevalence of BER gene polymorphisms in sporadic breast cancer.
Studies suggest that breast cancer is initiated by the induction of somatic mutations from errors in the base excision repair (BER) of endogenous estrogen-induced abasic sites. If so, the inheritance of certain polymorphic mutations in BER …
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Relative imbalances in the expression of estrogen-metabolizing enzymes in the breast tissue of women with breast carcinoma.
Estrogens are a known risk factor for breast cancer. Studies indicate that initiation of breast cancer may occur by metabolism of estrogens to form abnormally high levels of catechol estrogen-3,4-quinones, which can then react with DNA to f…