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Decreased Rac1 Cardiac Expression in Nitrofen-Induced Diaphragmatic Hernia.
[AIM] The high incidence of cardiac malformations in humans and animal models with congenital diaphragmatic hernia (CDH) is well known. The hypoplasia of left heart is common among fetuses with CDH and has been identified as a poor prognos…
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European Paediatric Surgeons' Association Survey on the Management of Hirschsprung Disease.
[UNLABELLED] This study aims to define patterns of Hirschsprung disease (HD) management. An online questionnaire was sent to all European Paediatric Surgeons' Association (EUPSA) members. A total of 294 members (61 countries) answered (r…
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Upregulation of S1P1 and Rac1 receptors in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia.
[PURPOSE] Sphingolipids play a crucial role in pulmonary development. The sphingosine kinase 1 (SphK1) modulates the synthesis of sphingolipid sphingosine-1-phosphate (S1P). S1P regulates cell proliferation and angiogenesis via different re…