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Recent Developments in Botulinum Neurotoxins Detection.
Botulinum neurotoxins (BoNTs) are produced as protein complexes by bacteria of the genus that are Gram-positive, anaerobic and spore forming (, , and spp.). BoNTs show a high immunological and genetic diversity. Therefore, fast, precise,…
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Regulatory Networks Controlling Neurotoxin Synthesis in and .
and are Gram-positive, spore-forming, and anaerobic bacteria that produce the most potent neurotoxins, botulinum toxin (BoNT) and tetanus toxin (TeNT), responsible for flaccid and spastic paralysis, respectively. The main habitat of these …
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In Silico Conformational Features of Botulinum Toxins A1 and E1 According to Intraluminal Acidification.
Although botulinum neurotoxins (BoNTs) are among the most toxic compounds found in nature, their molecular mechanism of action is far from being elucidated. A key event is the conformational transition due to acidification of the interior o…
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Is botulism type C transmissible to human by consumption of contaminated poultry meat? Analysis of a suspect outbreak in French Guyana.
Botulism type C was suspected in a 46-year old man after consumption of sick poultry from a flock where botulism type C was confirmed. The patient developed characteristic signs of botulism, but investigation of biological samples did not c…
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Infant botulism: Two case reports and electroneuromyogram findings.
Botulism is an uncommon severe neuromuscular disorder. We report two recent cases of confirmed infant botulism diagnosed in an 11-week and a 5-month-old infant along with electroneuromyogram (ENMG) findings. Then, we discuss the EMG feature…
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A penicillin- and metronidazole-resistant Clostridium botulinum strain responsible for an infant botulism case.
The clinical course of a case of infant botulism was characterized by several relapses despite therapy with amoxicillin and metronidazole. Botulism was confirmed by identification of botulinum toxin and Clostridium botulinum in stools. A C.…