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Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: implications for tumor development and progression.
Although growth factors and extracellular matrix (ECM) are recognized as important contributors to breast epithelial growth, morphogenesis, hormone responsiveness, and neoplastic progression, the influence of functional interactions between…
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Regulated CYP19 aromatase transcription in breast stromal fibroblasts.
Extraglandular estrogen synthesis mediates the proliferation of estrogen-responsive breast cancer in postmenopausal women. Aromatase, the cytochrome P450 Cyp19 enzyme, catalyzes the rate-limiting step in estrogen biosynthesis. Activity is p…
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Characterization of epithelial phenotypes in mortal and immortal human breast cells.
We have previously described the mortal human breast epithelial culture MCF-10M, that was derived from fibrocystic breast tissue, was cultivated in medium with low calcium content for over 2 years, and spontaneously gave rise to the immorta…